Automation of In Vitro Fertilization Laboratory Procedures Using the AURA Device in Assisted Reproductive Technology Treatment

What this Trial Is About

Researchers are evaluating the use of an automated system called AURA to assist in the laboratory part of Assisted Reproductive Technology ART treatment for infertility. The study focuses on patients undergoing intracytoplasmic sperm injection ICSI, where a single sperm is injected directly into an egg. This prospective cohort study aims to assess AURAs performance, including its automation level, efficiency, and throughput, while also comparing clinical outcomes of its subsystems to established benchmarks. The AURA device includes five subsystems that handle sperm preparation, egg retrieval from follicular fluid, egg denudation, fertilization, embryo culture, and cryopreservation. During treatment, sperm samples and cumulus-oocyte complexes COCs are processed using these subsystems. One in four eggs is randomly removed from the system for standard treatment, while the others proceed through the automated process. All automated steps are supervised by a laboratory manager who can intervene if needed. Participants provide sperm and eggs on the day of egg collection. Researchers will monitor and record procedural timings and automation levels over nine months. They will also assess sperm motility, fertilization rates, embryo development, cryosurvival, implantation rates, and clinical pregnancy outcomes. The study includes technical data collection on AURAs hardware and software functions. Participation lasts through the treatment cycle and related monitoring periods.

Automation of the In Vitro Fertilization Laboratory