Actively Recruiting
Autonomic Control of the Circulation and VDR
Led by Milton S. Hershey Medical Center · Updated on 2025-09-16
18
Participants Needed
1
Research Sites
354 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study objective of this project is to examine the mechanisms of the venous distension reflex (VDR) in humans. We hypothesize that COX blockade with ketorolac tromethamine, an intravenous NSAID, will attenuate the muscle sympathetic nerve activity (MSNA) response to limb venous distension. To gain further insight into whether the COX byproducts directly stimulate chemically-sensitive afferents, or enable venodilation and indirectly evoke afferent stimulation, we will measure vein size using 3T MRI during venous distention with and without ketorolac infusions.
CONDITIONS
Official Title
Autonomic Control of the Circulation and VDR
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Are capable of giving informed consent
- Are any race or ethnicity
- Are fluent in written and spoken English
- Have a satisfactory history and physical exam to meet inclusion/exclusion criteria
- Are free of acute or chronic medical conditions
- Are 21 - 35 years of age (inclusive)
- Weigh over 50 kg
You will not qualify if you...
- Are less than 21 or over 35 years of age
- Are pregnant or nursing women
- Are prisoners or institutionalized individuals or unable to consent
- Have any chronic diseases such as hypertension, heart, lung, neuromuscular disease, kidney disease, diabetes or cancer
- Are taking medications that may affect cardiovascular or nervous system
- Have taken an NSAID within 48 hours of any visit
- Have never taken NSAIDs and do not know if allergic
- Have a supine blood pressure greater than 140/90 mmHg
- Have known allergy to ibuprofen-like drugs (NSAIDs) or aspirin
- Have history of asthma or nasal polyps
- Have history of gastrointestinal bleeding or ulcers
- Have ferromagnetic metal implants
- Are claustrophobic
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here