Study of Blood Pressure and Heart Rate Control During Standing and Exercise in Healthy Young Adults and Older Adults with Hypertension

What this Trial Is About

Researchers are investigating how the autonomic nervous system controls blood pressure and heart rate during standing and exercise in both healthy adults and people with arterial hypertension. The study focuses on understanding cardiovascular responses to exercise on a cycle ergometer and includes groups with hypertension and related conditions like orthostatic hypotension and diabetes. This observational study aims to improve knowledge of cardiovascular regulation and may help identify autonomic dysfunction earlier for better clinical care. Participants include healthy young adults aged 18 to 35 without cardiovascular disease and several subgroups of older adults with controlled arterial hypertension, with or without orthostatic blood pressure abnormalities or diabetes. All participants undergo tests such as orthostatic testing, graded exercise on a cycle ergometer, electrocardiography, and arterial stiffness measurements like pulse wave velocity. Additional vascular and hemodynamic parameters are also recorded during these procedures. During the single study visit, researchers assess heart rate variability, blood pressure response to exercise, and heart rate recovery immediately after exercise. Clinical data including lab results and ambulatory blood pressure monitoring are collected from medical records for participants with hypertension. The study monitors cardiovascular function and autonomic regulation to contribute to better understanding and management of hypertension and related conditions.

Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals