Actively Recruiting
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
Led by University Medical Centre Ljubljana · Updated on 2026-03-19
120
Participants Needed
1
Research Sites
71 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical exercise. The main objective is to analyze cardiovascular responses to exercise on a cycle ergometer in different subgroups of participants with hypertension. The study includes healthy young adults and older adults with hypertension. Participants undergo standardized assessments including orthostatic testing, graded exercise testing on a cycle ergometer, electrocardiography, and measurement of arterial stiffness parameters such as pulse wave velocity, as well as other vascular and hemodynamic parameters. The results of this study are expected to improve understanding of cardiovascular physiology and autonomic regulation in people with hypertension and may contribute to earlier recognition of autonomic dysfunction and improved clinical management.
CONDITIONS
Official Title
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy volunteers aged 18-35 years without known acute or chronic disease
- Non-smokers
- Body mass index (BMI) between 20 and 24.9 kg/m�b2
- Negative orthostatic test
- Participants aged 60 years or older with arterial hypertension followed at the Department of Hypertension
- Controlled arterial hypertension with negative orthostatic test and without diabetes mellitus
- Controlled arterial hypertension with positive orthostatic test indicating orthostatic hypotension
- Controlled arterial hypertension with positive orthostatic test indicating a rise in blood pressure during orthostatic testing
- Controlled arterial hypertension and diabetes mellitus without previously diagnosed autonomic dysfunction
- Ability to provide written informed consent
You will not qualify if you...
- Dementia, neurodegenerative disease, or cognitive impairment preventing understanding of study procedures
- Known cardiovascular disease including heart failure (NYHA II-IV), myocardial infarction within previous 6 months, significant arrhythmias, or peripheral arterial occlusive disease
- Uncontrolled arterial hypertension
- Change in antihypertensive therapy within previous 4 weeks
- Presence of a cardiac pacemaker
- Treatment with antiarrhythmic drugs (class I, III, or IV), digoxin, alpha-receptor blockers, or other medications affecting heart rate variability or autonomic function
- Advanced renal failure (eGFR <30 mL/min/1.73 m�b2) or advanced liver failure
- Active malignancy
- Body mass index 35 kg/m�b2 or higher
- Acute illness within previous 4 weeks
- Current smoking
- Inability to safely perform exercise testing on a cycle ergometer
- Severe psychiatric disorders without stable treatment
- Pregnancy or breastfeeding
- Participation in another clinical study
- Refusal or inability to provide written informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Medical Centre Ljubljana
Ljubljana, Slovenia, 1000
Actively Recruiting
Research Team
A
Amela Kabaklić, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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