Actively Recruiting
AUTONOMOUS DISORDERS IN CMT
Led by University Medical Center Goettingen · Updated on 2026-05-06
50
Participants Needed
1
Research Sites
3 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hereditary neuropathies are a diverse group of disorders that include Charcot-Marie-Tooth disease (CMT), which has different types such as CMT1 and CMT2. This research aims to study autonomic nervous system problems in people with CMT, which can affect daily life and quality of life. The study will assess how common and severe these autonomic issues are, and whether they differ among CMT subtypes, helping to better understand and care for patients with CMT. Participants include adults diagnosed with CMT and healthy age-matched controls. The study involves using questionnaires and non-invasive tests to evaluate autonomic dysfunction. Patient histories will be reviewed for diagnosis details, genetic confirmation, disease duration, neurological impairment, and other health conditions. Measurements such as muscle strength, nerve studies, and nerve ultrasound will be collected during visits. Participants will have baseline assessments including the COMPASS 31 questionnaire and electrophysiological tests. Additional evaluations like neurography and nerve sonography will be done to understand nerve function. The study aims to gather detailed data on autonomic and neurological function to identify risk factors and differences between CMT types. The total participation duration and follow-up details are based on study visits, with all participants consenting to join.
CONDITIONS
Brief Title
AUTONOMOUS DISORDERS IN CMT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of Charcot-Marie-Tooth disease or anamnestically healthy control group
- Genetic confirmation of CMT in adult patients
- Ability to complete baseline outcome measures
- Age between 18 and 65 years
- Capacity to consent and signed informed consent form
You will not qualify if you...
- Pregnancy or breastfeeding
- Other relevant neurological or psychiatric disorders, current or past
- Presence of a serious previous internal disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo baseline assessments including COMPASS 31 questionnaire, electrophysiological measurements, muscle strength tests, neurography, and nerve sonography.
1 visit (in-person)
Duration - Up to 4 years
Participants are observed without intervention to monitor autonomic disorders in Charcot-Marie-Tooth disease and healthy controls over time.
Visits as needed for follow-up assessments
Trial Site Locations
Total: 1 location
1
University Medical Centre
Göttingen, Lower Saxony, Germany, 37075
Actively Recruiting
Research Team
M
Michael W Sereda, Prof. MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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