Actively Recruiting
Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Led by Centre Hospitalier Universitaire de Nīmes · Updated on 2026-05-06
50
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pregnancy increases the risk of thrombosis. Placenta-mediated diseases are a risk factor for cardiovascular pathologies and can lead to maternal-fetal morbidity and mortality. It is essential to understand the cellular and molecular mechanisms of dysfunctions at the vascular-placental interface so that systemic vascular risk can be characterized and, ultimately, screened for, on the basis of new markers (targeted preventive management). Deregulated autophagy could be the starting point for cell death by apoptosis or necrosis leading to complications. The pathophysiological mechanisms involved in trophoblast apoptosis are incompletely described. This project follows on from the GrossAuTop-1 study, which investigated the intra- and inter-individual variability of autophagy and apoptosis activities in women during pregnancy. The aim of this project is to study autophagy and apoptosis activities specifically in women developing a placental vascular complication during pregnancy.
CONDITIONS
Official Title
Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women with placental vascular complications such as preeclampsia or intrauterine growth retardation, hospitalized and delivering at Nimes University Hospital
- Pregnant women able to give free and informed consent
- Pregnant women covered by a health insurance plan
You will not qualify if you...
- Multiple pregnancy (twins or more)
- High blood pressure and/or proteinuria present before pregnancy
- Participation in another interventional drug study
- Currently excluded by another study's rules
- Under court protection, guardianship, or curatorship
- Unable to give consent
- Unable to receive informed information
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Nimes University Hospital
Nîmes, France
Actively Recruiting
Research Team
S
Sylvie BOUVIER, Dr.
CONTACT
A
Anissa MEGZARI
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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