Actively Recruiting
Study of the Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Led by Centre Hospitalier Universitaire de Nīmes · Updated on 2026-05-06
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pregnancy raises the risk of blood clots and complications related to the placenta, which can cause serious health issues for both mother and baby. Researchers are studying the balance between autophagy (cell maintenance) and apoptosis (cell death) in the placenta to better understand how these processes may contribute to placental vascular diseases like preeclampsia and intrauterine growth retardation. This study builds on previous research that looked at these cell activities in normal pregnancies. The study involves pregnant women who develop placental vascular complications and are hospitalized at Nimes University Hospital. Blood and urine samples will be collected at the start, then monthly during pregnancy follow-up visits, and again at delivery. These samples will be tested to measure specific proteins related to autophagy and apoptosis, as well as other markers linked to vascular and kidney function. Participants will undergo regular monitoring through blood and urine tests to track changes in cell activity and other biological markers from the start of the study until delivery. Researchers will analyze these samples to understand the cellular mechanisms involved in the placental complications. The study aims to provide new insights that could lead to better screening and prevention strategies for these pregnancy-related vascular problems.
CONDITIONS
Brief Title
Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women developing a placental vascular complication such as preeclampsia and/or intrauterine growth retardation, hospitalized and delivering at Nimes University Hospital
- Pregnant women who provide free and informed consent
- Pregnant women affiliated with or benefiting from a health insurance scheme
You will not qualify if you...
- Multiple pregnancy
- Presence of hypertension and/or proteinuria before pregnancy
- Participation in any interventional drug study
- Being excluded due to another study's rules
- Persons under court protection, guardianship, or curatorship
- Persons unable to give consent
- Persons for whom it is impossible to provide informed information
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to a few days before inclusion
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Monthly visits until delivery (up to 4 months)
Participants are monitored during pregnancy with monthly blood and urine sample collections to study autophagy and apoptosis activities related to placental vascular complications.
Monthly visits with blood and urine sample collection
Duration - Day of delivery
At delivery, participants undergo blood sampling as part of usual care with additional blood samples collected for study purposes.
1 visit (in-person) at delivery
Trial Site Locations
Total: 1 location
1
Nimes University Hospital
Nîmes, France
Actively Recruiting
Research Team
S
Sylvie BOUVIER, Dr.
A
Anissa MEGZARI
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here