Study of Anti-RoSSA IgE Levels to Assess Disease Activity in Adults with Primary Sjgrens Syndrome

What this Trial Is About

Primary Sjf6grens syndrome pSS is a chronic autoimmune disease that affects multiple organs and leads to decreased quality of life. The condition often has periods of flares and relapses, making reliable biomarkers important for tracking disease activity. Researchers are studying the presence of anti-RoSSA IgE antibodies as a potential biomarker to better determine pSS activity, given their role in autoimmune responses and interferon alpha signaling. Participants with primary Sjf6grens syndrome will have blood samples taken to measure anti-RoSSA IgE levels using an ELISA test. This observational study includes patients diagnosed according to the American-European Consensus Criteria. The study focuses on comparing antibody presence with disease activity and other clinical features. During the study, participants will provide blood samples at the start to assess antibody levels. Researchers will collect data on disease activity using the Eular Sjf6gren Syndrome Disease Activity Index and related symptom scores. The study will explore correlations between antibody presence and disease features, including lymphoma onset and interferon alpha signature, with some outcomes reviewed over five years.

Autoreactive Anti-Ro/SSA IgE To Determine Primary SjögRen's Syndrome's Disease Activity