Actively Recruiting
Autosomal Dominant Spinocerebellar Ataxias and Social Cognition
Led by University Hospital, Angers · Updated on 2026-02-05
160
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Spinocerebellar ataxias are a group of rare neurodegenerative diseases, clinically and genetically highly heterogeneous, with an estimated mean prevalence of 2.7 per 100,000 population. The term "spinocerebellar ataxia" or "SCA" is often used for ataxias of genetic origin of autosomal dominant transmission, which are the subject of this study. Recent studies of social cognition in patients with genetic cerebellar pathologies, and autosomal dominant spinocerebellar ataxia in particular, are still few and far between (around 15 studies), and seem to highlight impairment of basic emotion recognition and theory of mind skills. That said, data have very often been collected on very small samples of patients (sometimes in case study format). They also remain contradictory, including in the examination of the cerebellar anatomoclinical correlates of the deficits. Thus, the question arises as to whether patients with spinocerebellar ataxia also show impairments in emotion recognition and cognitive and affective theory of mind in more ecologically valid dynamic and interactive assessment situations.
CONDITIONS
Official Title
Autosomal Dominant Spinocerebellar Ataxias and Social Cognition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men or women aged 18 and over
- At least 7 years' schooling (CEP level)
- Ability to read, write and speak French
- Signed informed consent to participate in the study
- For patients: Molecularly confirmed autosomal dominant spinocerebellar ataxia (SCA1, 2, 3, 6, 7, 27B)
- For controls: No neurological pathology based on questioning and neurological exam
You will not qualify if you...
- Participation in another study that could interfere with study measurements
- Physical or cultural factors that might affect test performance
- History of conditions affecting cognition (stroke, brain injury, other neurodegenerative diseases, epilepsy, learning disabilities, alcohol dependence, psychiatric disorders)
- Contraindications to MRI scans
- Pregnant, nursing, or recently delivered women
- Persons deprived of liberty by court or administrative order
- Persons under compulsory psychiatric care
- Persons under legal protection measures
- Persons unable to provide consent
- Persons not affiliated with or benefiting from a social security scheme
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU Angers
Angers, France, 49933
Actively Recruiting
Research Team
P
Philippe Allain, professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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