Actively Recruiting

Phase Not Applicable
Age: 18Years - 85Years
All Genders
NCT05776797

AV Junction Ablation or Optimal Medical Treatment in PatiEnts With Cardiac Resynchronization Therapy and Permanent Atrial Fibrillation

Led by University Hospital Ostrava · Updated on 2023-06-08

480

Participants Needed

9

Research Sites

313 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

A study comparing atrioventricular junction ablation (AVJA) versus continued optimum medical rate control in patients with cardiac resynchronization therapy (CRT) and atrial fibrillation (AF) with suboptimal heart rate control on optimum medication.

CONDITIONS

Official Title

AV Junction Ablation or Optimal Medical Treatment in PatiEnts With Cardiac Resynchronization Therapy and Permanent Atrial Fibrillation

Who Can Participate

Age: 18Years - 85Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Treatment with CRT using either a biventricular pacemaker/defibrillator or conduction system pacemaker for more than 6 months
  • Diagnosis of atrial fibrillation classified as permanent or recurrent persistent AF requiring emergency visits or hospitalizations at least once in the past year
  • Optimized heart failure medical treatment and rate control medication
  • Biventricular pacing percentage plus ventricular premature complex percentage between 85% and less than 99% for at least one month while on optimal medical therapy (for permanent AF patients)
  • Age greater than 18 and less than 85 years
  • Signed informed consent
Not Eligible

You will not qualify if you...

  • Myocardial infarction or coronary artery bypass graft within the past 3 months
  • Technical failure of the cardiac resynchronization therapy system
  • Intentional preference for spontaneous atrioventricular conduction
  • Expected survival less than 1 year
  • Other significant comorbidities or conditions interfering with trial conduction
  • Dementia as assessed by mini-mental test score less than 23 points

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 9 locations

1

Regional Hospital Liberec

Liberec, Liberec Region, Czechia, 460 01

Actively Recruiting

2

University Hospital Ostrava

Ostrava, Moravian-Silesian Region, Czechia, 70852

Actively Recruiting

3

Hospital Podlesí, Inc.

Třinec, Moravian-Silesian Region, Czechia, 739 61

Actively Recruiting

4

University Hospital Olomouc

Olomouc, Olomouc Region, Czechia, 779 00

Actively Recruiting

5

Hospital České Budějovice

České Budějovice, South Bohemian Region, Czechia, 370 01

Actively Recruiting

6

St. Anne's University Hospital Brno

Brno, South Moravian, Czechia, 602 00

Actively Recruiting

7

University Hospital Brno

Brno, South Moravian, Czechia, 625 00

Actively Recruiting

8

Institute of Clinical and Experimental Medicine

Prague, Czechia, 14021

Actively Recruiting

9

Military University Hospital Prague

Prague, Czechia, 169 02

Actively Recruiting

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Research Team

J

Jiří Hynčica

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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AV Junction Ablation or Optimal Medical Treatment in PatiEnts With Cardiac Resynchronization Therapy and Permanent Atrial Fibrillation | DecenTrialz