Actively Recruiting
AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function
Led by St. Josefs-Hospital Wiesbaden GmbH · Updated on 2026-02-24
86
Participants Needed
2
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
AVA CONDUCT is a prospective, multicenter, randomized study with single blinding, comparing left bundle branch area (LBBA) pacing with right ventricular (RV) pacing following AV node ablation in terms of clinical, functional, and electrophysiological outcomes. The primary hypothesis is that pacing-induced cardiomyopathy, defined as a decrease in LVEF by 10% or more from baseline to an absolute value below 50%, occurs significantly more frequently in patients receiving RV pacing compared with LBBA pacing. Secondarily, LBBA pacing is expected to maintain comparable procedural safety while providing better cardiac function, resulting in improved quality of life and functional capacity compared with conventional RV pacing.
CONDITIONS
Official Title
AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of symptomatic atrial fibrillation despite guideline-indicated medical or interventional therapy
- Preserved left ventricular ejection fraction of 50% or higher by echocardiography
- Scheduled for AV node ablation independently of study participation
- Age 18 years or older
- Ability to give informed consent
You will not qualify if you...
- Left ventricular ejection fraction below 50%
- Existing pacemaker implanted before the study
- Contraindication for pacemaker implantation or AV node ablation
- Severe left heart valve disease (high grade III°)
- Recent coronary surgery within 30 days or ongoing triple therapy after stent PCI
- Body mass index over 40 kg/m2
- Pregnancy
- Unable to provide written informed consent
- Life expectancy less than 12 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Evangelisches Krankenhaus Hagen-Haspe
Hagen, Germany
Not Yet Recruiting
2
St. Josefs-Hospital Wiesbaden GmbH
Wiesbaden, Germany
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here