Actively Recruiting
Avatrombopag for Platelet Recovery Post-UCBT in Patients With Bone Marrow Failure Disease
Led by Anhui Provincial Hospital · Updated on 2024-12-31
40
Participants Needed
1
Research Sites
95 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To evaluate the efficacy and safety of Avatrombopag for platelet recovery after unrelated cord blood transplantation (UCBT) in patients with bone marrow failure disease
CONDITIONS
Official Title
Avatrombopag for Platelet Recovery Post-UCBT in Patients With Bone Marrow Failure Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 6 years old, male or female
- Diagnosed with bone marrow failure disease including aplastic anemia, Fanconi anemia, paroxysmal nocturnal hemoglobinuria
- Undergoing unrelated cord blood transplantation (UCBT)
- ECOG score 6
- Voluntary participation with informed consent
You will not qualify if you...
- Pregnant or lactating women
- Known allergy to Avatrombopag
- History of severe thrombotic events or active thromboembolism requiring anticoagulation
- History of platelet dysfunction, bleeding prone disease, or severe bleeding within 7 days before screening
- Chronic active hepatitis B or C
- Repeat, multiple, or multiple organ transplantation
- HIV positive, EBV-DNA positive, or CMV-DNA positive
- Severe infection or serious heart, liver, lung, kidney, neurological, or metabolic diseases
- Serious adverse event (Level 4 or 5) during pre-treatment period
- Participation in another clinical trial with exploratory drug or device within 30 days before baseline
- Cognitive impairment or uncontrolled mental illness
- Refusal of treatment with Avatrombopag by participant or authorized family
- Judged unsuitable by researchers due to medical history or inability to adhere to treatment due to financial problems
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Hefei, Anhui, China, 230036
Actively Recruiting
Research Team
X
Xiaoyu Zhu, ph.D
CONTACT
A
Aijie Huang, M.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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