Actively Recruiting
AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)
Led by Avenzo Therapeutics, Inc. · Updated on 2026-05-13
480
Participants Needed
18
Research Sites
286 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study, the first clinical trial of AVZO-1418, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-1418 when administered intravenously as a monotherapy and potentially in combination therapy to patients with locally advanced or metastatic epithelial solid tumors.
CONDITIONS
Official Title
AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75 years with ECOG Performance Status of 0 or 1 and life expectancy over 3 months
- Histologically or cytologically confirmed locally advanced or metastatic epithelial solid tumors as specified in the protocol
- Measurable disease by RECIST v1.1 assessment
- Willingness to provide molecular test reports and tumor samples or fresh biopsy
- Other protocol-defined inclusion criteria
You will not qualify if you...
- Uncontrolled high blood pressure
- Active central nervous system metastases; treated, stable brain metastases without steroid treatment are allowed
- Suspected or confirmed leptomeningeal disease
- History of drug-induced interstitial lung disease
- History of serious cardiovascular conditions
- Infection requiring IV antibiotics, antivirals, or antifungals within 2 weeks before first dose
- History of solid organ transplant
- Other protocol-defined exclusion criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 18 locations
1
Avenzo Therapeutics Recruiting Site
Gilbert, Arizona, United States, 85234
Actively Recruiting
2
Avenzo Therapeutics Recruiting Site
Los Angeles, California, United States, 90048
Actively Recruiting
3
Avenzo Therapeutics Recruiting Site
Denver, Colorado, United States, 80218
Actively Recruiting
4
Avenzo Therapeutics Recruiting Site
New Haven, Connecticut, United States, 06510
Actively Recruiting
5
Avenzo Therapeutics Recruiting Site
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
6
Avenzo Therapeutics Recruiting Site
Orlando, Florida, United States, 32827
Actively Recruiting
7
Avenzo Therapeutics Recruiting Site
Sarasota, Florida, United States, 34232
Actively Recruiting
8
Avenzo Therapeutics Recruiting Site
Tampa, Florida, United States, 33612
Actively Recruiting
9
Avenzo Therapeutics Recruiting Site
Atlanta, Georgia, United States, 30322
Actively Recruiting
10
Avenzo Therapeutics Recruiting Site
Boston, Massachusetts, United States, 02215
Actively Recruiting
11
Avenzo Therapeutics Recruiting Site
New York, New York, United States, 10029
Actively Recruiting
12
Avenzo Therapeutics Recruiting Site
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
13
Avenzo Therapeutics Recruiting Site
Dallas, Texas, United States, 75039
Actively Recruiting
14
Avenzo Therapeutics Recruiting Site
Houston, Texas, United States, 77054
Actively Recruiting
15
Avenzo Therapeutics Recruiting Site
San Antonio, Texas, United States, 78229
Actively Recruiting
16
Avenzo Therapeutics Recruiting Site
West Valley City, Utah, United States, 84119
Actively Recruiting
17
Avenzo Therapeutics Recruiting Site
Fairfax, Virginia, United States, 22031
Actively Recruiting
18
Avenzo Therapeutics Recruiting Site
Seattle, Washington, United States, 98109
Actively Recruiting
Research Team
M
Medical Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
4
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