Actively Recruiting

Phase 4
Age: 21Years +
All Genders
NCT06474299

The Avenues Study: Dual Use Cessation

Led by University of Wisconsin, Madison · Updated on 2026-04-13

500

Participants Needed

1

Research Sites

196 weeks

Total Duration

On this page

Sponsors

U

University of Wisconsin, Madison

Lead Sponsor

N

National Cancer Institute (NCI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The overarching goal of this research is to determine the most effective approach for helping dual users of cigarettes and electronic nicotine delivery systems (ENDS) quit smoking. 500 participants will be enrolled and can expect to be on study for 12 months.

CONDITIONS

Official Title

The Avenues Study: Dual Use Cessation

Who Can Participate

Age: 21Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Able to read and communicate in English
  • Willing to set a quit date to quit smoking cigarettes in the next 30 days
  • Willing and medically able to use varenicline and nicotine patches
  • Smoking 6 5 cigarettes per day for the past 6 months
  • Vaping weekly for at least 6 months
  • Willing to stop using nicotine replacement or varenicline
  • Willing to stop using bupropion if currently using it only for smoking cessation
  • Saliva cotinine >20 ng/ml
  • US resident
  • Own a smartphone to use and download an app
  • Have a working email to receive video visit links
Not Eligible

You will not qualify if you...

  • Currently in treatment for psychosis or bipolar disorder
  • Currently taking bupropion for non-smoking cessation reasons
  • Currently pregnant or breastfeeding; if pregnancy occurs during the study, participant may continue without study medications and must return unused medications

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Wisconsin-Madison School of Medicine and Public Health

Madison, Wisconsin, United States, 53792

Actively Recruiting

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Research Team

M

Mark Zehner

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

FACTORIAL

Primary Purpose

TREATMENT

Number of Arms

8

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