Actively Recruiting
Avocado and Postprandial Responses
Led by University of Vermont Medical Center · Updated on 2025-03-28
30
Participants Needed
1
Research Sites
65 weeks
Total Duration
On this page
Sponsors
U
University of Vermont Medical Center
Lead Sponsor
A
Avocado Nutrition Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating. The investigators will test the effects of 3 breakfast meals on blood sugar control and signals of hunger and fullness after eating: 1. Whole-wheat bread and strawberry jam 2. Whole-wheat bread, strawberry jam, and avocado 3. Whole-wheat bread and strawberry jam (meal enriched with fat and fiber to mimic that of an avocado) Participants will undergo 3 test periods, each separated by a week. Each test period consists of one day with set meals that the investigators will provide (breakfast, lunch, and dinner), and then the next morning, participants will eat a breakfast meal and have blood drawn several times over 4 hours.
CONDITIONS
Official Title
Avocado and Postprandial Responses
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biological sex males or females
- Age 21 to 65 years
- Body mass index (BMI) between 18.5 and 34.9 kg/m2
You will not qualify if you...
- Actively pregnant or lactating women
- Diagnosis of prediabetes or diabetes (fasting glucose >100 mg/dL)
- Uncontrolled hypertension (systolic BP >160 mmHg or diastolic BP >95 mmHg), unless on stable treatment for at least one month
- Uncontrolled hyperlipidemia (fasting total cholesterol >200 mg/dL or fasting triglycerides >200 mg/dL), unless on stable treatment for at least one month
- Presence of kidney disease, liver disease, hyperthyroidism, untreated or unstable hypothyroidism, certain cancers, gastrointestinal disease, pancreatic disease, other chronic metabolic diseases or malabsorption syndromes, HIV, or inflammatory conditions such as arthritis, asthma, Crohn's disease, inflammatory bowel disease, gout, or lupus
- History of bariatric or certain other weight control surgeries
- Use of medications that lower blood glucose or affect weight, appetite, or gut motility
- Smoking or use of tobacco products within 6 months prior to study start
- Antibiotic use during the intervention or within 3 weeks prior to any treatment period
- History of eating disorders or significant food preferences interfering with the diet intervention
- Allergies or adverse reactions to study foods or food aversions interfering with diet adherence
- Body weight loss greater than 10% within the last 6 months
- Unable or unwilling to give informed consent or communicate with study staff
- Alcohol or substance abuse within the past 12 months or current treatment for these problems
- Other medical, psychiatric, or behavioral factors that may interfere with participation
- Undergoing hormonal therapy, except stable regimen for at least 6 months prior to study start
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Clinical Research Center, University of Vermont Medical Center
Burlington, Vermont, United States, 05405
Actively Recruiting
Research Team
C
Clinical Research Project Manager
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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