Actively Recruiting

Phase Not Applicable
Age: 21Years - 65Years
All Genders
Healthy Volunteers
ID06818032

Acute Avocado Consumption on Postprandial Glycemic and Appetite/Satiety Responses

Led by University of Vermont Medical Center · Updated on 2025-03-28

30

Participants Needed

1

Research Sites

17 weeks

Total Duration

On this page

Sponsors

U

University of Vermont Medical Center

Lead Sponsor

A

Avocado Nutrition Center

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to evaluate how adding avocado to a breakfast meal affects blood sugar control and feelings of hunger and fullness after eating in healthy adults aged 21 to 65 years. The study compares three different breakfast meals to understand their impact on post-meal glucose levels and appetite signals. The investigation is sponsored by the University of Vermont Medical Center and includes healthy volunteers without certain medical conditions or treatments that could affect metabolism. Participants will experience three test periods, each separated by one week. During each period, they will consume set meals provided by the researchers, including breakfast, lunch, and dinner. The breakfast meals tested include: whole-wheat bread with strawberry jam; whole-wheat bread, jam, and avocado; and whole-wheat bread with jam enriched with fat and fiber to resemble avocado. Each test period lasts one day for meal consumption, followed by blood draws over four hours the next morning after eating the breakfast meal. Throughout the study, participants will have blood samples taken multiple times to measure changes in blood sugar levels at specific time points and appetite-related hormones. Researchers will monitor diet-induced glucose tolerance and hormone responses to assess how each meal influences postprandial metabolic and satiety outcomes. The entire participation involves three separate one-day test periods with one-week breaks between them, allowing close observation of post-meal responses under controlled dietary conditions.

CONDITIONS

Brief Title

Avocado and Postprandial Responses

Who Can Participate

Age: 21Years - 65Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Biological sex males or females
  • Age 21 to 65 years
  • Body mass index (BMI) between 18.5 and 34.9 kg/m2
Not Eligible

You will not qualify if you...

  • Actively pregnant or lactating women
  • Diagnosis of prediabetes or diabetes with fasting glucose over 100 mg/dL
  • Uncontrolled hypertension with systolic BP over 160 mmHg or diastolic BP over 95 mmHg
  • Uncontrolled hyperlipidemia with fasting total cholesterol over 200 mg/dL or triglycerides over 200 mg/dL
  • Presence of kidney, liver, thyroid, pancreatic, gastrointestinal, certain cancers, HIV, or inflammatory diseases
  • History of bariatric or certain weight control surgeries
  • Use of medications that lower blood glucose or affect weight, appetite, or gut motility
  • Smoking or tobacco use within 6 months prior to the study
  • Antibiotic use during the intervention or within 3 weeks before treatment
  • History of eating disorders or significant food preferences interfering with diet
  • Allergies or intolerances to study foods or aversions affecting adherence
  • Body weight loss greater than 10% within the last 6 months
  • Unable or unwilling to give informed consent or communicate with study staff
  • Alcohol or substance abuse within the past 12 months or current treatment
  • Other medical, psychiatric, or behavioral factors interfering with participation
  • Hormonal therapy unless on a stable regime for at least 6 months prior to study start

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Duration of the intervention period as per protocol

Participants will consume different breakfast meals including a bread and jam breakfast with and without avocado, and a bread and jam breakfast enriched with fat and fiber, to study effects on blood sugar and satiety.

Multiple visits for each breakfast condition as part of a crossover design

Trial Site Locations

Total: 1 location

1

Clinical Research Center, University of Vermont Medical Center

Burlington, Vermont, United States, 05405

Actively Recruiting

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Research Team

C

Clinical Research Project Manager

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

3

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Published Research Related To This Trial

Using the Avocado to Test the Satiety Effects of a Fat-Fiber Combination in Place of Carbohydrate Energy in a Breakfast Meal in Overweight and Obese Men and Women: A Randomized Clinical Trial.

Lanjun Zhu, Yancui Huang, Indika Edirisinghe...

https://pubmed.ncbi.nlm.nih.gov/31035472

Metabolic Effects of Monounsaturated Fatty Acid-Enriched Diets Compared With Carbohydrate or Polyunsaturated Fatty Acid-Enriched Diets in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Frank Qian, Andres Ardisson Korat, Vasanti Malik...

https://pubmed.ncbi.nlm.nih.gov/27457635

Avocado Fruit on Postprandial Markers of Cardio-Metabolic Risk: A Randomized Controlled Dose Response Trial in Overweight and Obese Men and Women.

Eunyoung Park, Indika Edirisinghe, Britt Burton-Freeman

https://pubmed.ncbi.nlm.nih.gov/30213052

Greater diet quality is associated with more optimal glycemic control in a longitudinal study of youth with type 1 diabetes.

Tonja R Nansel, Leah M Lipsky, Aiyi Liu

https://pubmed.ncbi.nlm.nih.gov/27194309