Feasibility Study of Using Ultrasound to Detect and Avoid Insulin Injection Lipohypertrophy in Adults With Diabetes

What this Trial Is About

Diabetes is a common long-term health condition affecting many people worldwide. Both type 1 diabetes, which requires insulin from diagnosis, and type 2 diabetes, which often requires insulin as it progresses, can lead to a complication called lipohypertrophy Lipos. Lipos are fatty lumps that form at insulin injection sites and can disrupt insulin absorption, causing fluctuations in blood glucose levels. This study aims to find out if avoiding Lipos detected by ultrasound scanning can improve glucose control in people with diabetes who use continuous glucose monitoring and experience significant glucose variability. Participants will receive a clinical examination and an ultrasound scan of their insulin injection sites. If Lipos are found, participants will be given a personalized map of these sites and advised to avoid injecting insulin there for 24 weeks. They will also receive education on proper insulin injection techniques, including needle length and injection methods. Follow-up visits will occur remotely or in person at 4 and 12 weeks, with a final visit at 24 weeks including repeat clinical examination and ultrasound scanning to assess changes. Throughout the study, continuous glucose monitoring data will be collected to evaluate time spent in the target glucose range and other glucose measures. Blood samples for HbA1c and kidney function will be taken at the beginning and end of the study. The study will also train diabetes care teams to perform ultrasound scans to detect Lipos. Overall participation lasts about 24 weeks, with data collected on glucose control, insulin doses, and lipohypertrophy resolution.

Avoidance of Insulin-induced Lipohypertophy in People With Diabetes Using Ultrasound Scanning Within Diabetes Clinics