Actively Recruiting
Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
Led by University Hospital, Tours · Updated on 2026-05-04
1078
Participants Needed
38
Research Sites
461 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently leads to tracheal intubation and poor outcome. Among invasively mechanically ventilated patients with ARDS and presenting a PaO2/FiO2 ratio (arterial partial pressure of oxygen to inspired fraction of oxygen) of less than 150 mmHg, the prone position significantly reduces mortality and represents standard care (Guérin 2013). Among non-intubated COVID-19 patients, a subtype of viral community acquired pneumonia, a recent study showed that awake prone positioning reduces the composite outcome of intubation or death among patients requiring nasal high flow therapy. Furthermore, it favored weaning of nasal high flow therapy. Prone position in patients with non-COVID ARDS treated with high nasal flow was evaluated in 20 patients with predominantly viral pneumonia (Ding 2020) and was associated with improved oxygenation. Coordinating investigator hypothesize that prone positioning of patients suffering non-COVID community acquired pneumonia and undergoing nasal high flow therapy can significantly improve outcome by reducing the need for intubation and associated therapies such as sedation and muscle relaxation.
CONDITIONS
Official Title
Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients admitted to an intensive care unit or intermediate care unit
- Suspicion of community acquired pneumonia with at least one symptom: fever, cough, or purulent expectoration
- Chest X-ray or CT scan showing abnormalities suggestive of pneumonia
- PaO2/FiO2 ratio less than 300 mmHg (or equivalent SpO2/FiO2 less than 315 mmHg) with at least 30 L/min gas flow
- Affiliated to a French social security system or equivalent
- Provided informed consent
You will not qualify if you...
- Positive SARS-COV2 test within the last 30 days
- Need for immediate intubation
- "Do not intubate" decision made
- Chest trauma or other reasons preventing prone positioning
- Formal indication for non-invasive ventilation such as COPD exacerbation or acute cardiogenic pulmonary edema
- Pregnant or breastfeeding women
- Under legal protection measures
- More than 8 hours of awake prone positioning before inclusion
- More than 48 hours since admission to intensive or intermediate care unit
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 38 locations
1
Intensive care, University Hospital, Amiens
Amiens, France
Not Yet Recruiting
2
Intensive care, University Hospital, Angers
Angers, France
Not Yet Recruiting
3
Intensive care, University Hospital, Argenteuil
Argenteuil, France
Not Yet Recruiting
4
Intensive care, University Hospital, Belfort
Belfort, France
Not Yet Recruiting
5
Intensive care, University Hospital, Besancon
Besançon, France
Not Yet Recruiting
6
Intensive care, University Hospital, Bethune
Béthune, France
Not Yet Recruiting
7
Intensive care, University Hospital, Blois
Blois, France
Not Yet Recruiting
8
Intensive care, University Hospital, Bordeaux
Bordeaux, France
Not Yet Recruiting
9
Intensive care, University Hospital, Bourg en Bresse
Bourg-en-Bresse, France
Not Yet Recruiting
10
Intensive care, University Hospital, Bourges
Bourges, France
Actively Recruiting
11
Intensive care, University Hospital, Brest
Brest, France
Not Yet Recruiting
12
Intensive care, University Hospital, Colombes
Colombes, France
Not Yet Recruiting
13
Intensive care, University Hospital, Dieppe
Dieppe, France
Not Yet Recruiting
14
Intensive care, University Hospital, Dijon
Dijon, France
Actively Recruiting
15
Intensive care, University Hospital, Dreux
Dreux, France
Not Yet Recruiting
16
Intensive care, University Hospital, Garches
Garche, France
Not Yet Recruiting
17
Intensive care, University Hospital, Grenoble
Grenoble, France
Not Yet Recruiting
18
Intensive care, University Hospital, La Roche sur Yon
La Roche-sur-Yon, France
Actively Recruiting
19
Intensive care, University Hospital, Le Mans
Le Mans, France
Actively Recruiting
20
Intensive care, University Hospital, Lens
Lens, France
Actively Recruiting
21
Intensive care, University Hospital, Lille
Lille, France
Not Yet Recruiting
22
Intensive care, University Hospital, Lorient
Lorient, France
Not Yet Recruiting
23
Intensive care, University Hospital, Lyon
Lyon, France
Not Yet Recruiting
24
Intensive care, University Hospital, Lyon
Lyon, France
Not Yet Recruiting
25
Intensive care, University Hospital, Morlaix
Morlaix, France
Actively Recruiting
26
Intensive care, University Hospital, Nantes
Nantes, France
Actively Recruiting
27
Intensive care, University Hospital, Nice
Nice, France
Not Yet Recruiting
28
Intensive care, University Hospital, Nice
Nice, France
Not Yet Recruiting
29
Intensive care, University Hospital, Orléans
Orléans, France
Not Yet Recruiting
30
Intensive care, University Hospital, Cochin
Paris, France
Not Yet Recruiting
31
Intensive care, University Hospital, Tenon
Paris, France
Not Yet Recruiting
32
Intensive care, University Hospital, Poitiers
Poitiers, France
Actively Recruiting
33
Intensive care, University Hospital, Rouen
Rouen, France
Not Yet Recruiting
34
Intensive care, University Hospital, Saint Brieuc
Saint-Brieuc, France
Actively Recruiting
35
Intensive care, University Hospital, Saint Nazaire
Saint-Nazaire, France
Actively Recruiting
36
Intensive care, University Hospital, Strasbourg
Strasbourg, France
Not Yet Recruiting
37
Intensive care, University Hospital, Strasbourg
Strasbourg, France
Not Yet Recruiting
38
Intensive care, University Hospital, Tours
Tours, France
Actively Recruiting
Research Team
S
Stephan EHRMANN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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