Actively Recruiting
Led by Casper Rokx · Updated on 2026-03-12
5200
Participants Needed
28
Research Sites
43 weeks
Total Duration
C
Casper Rokx
Lead Sponsor
V
ViiV Healthcare
Collaborating Sponsor
This research aims to evaluate whether creating dedicated HIV teams in hospitals across ten European countries can increase HIV testing rates among patients showing signs of HIV-related conditions. The study uses a stepped-wedge design, where hospitals switch from routine care to the new intervention in sequence. This approach compares outcomes before and after the teams are in place, helping to understand the impact of the intervention across various locations and medical specialties. The intervention involves establishing local HIV teams led by specialists and supported by nurses and data experts. These teams identify patients needing HIV tests through electronic health records, provide feedback to doctors to encourage testing, offer education to healthcare staff about HIV, reduce stigma, and improve connections to prevention and care services. This program integrates smoothly into regular hospital routines and aims to close gaps in HIV diagnosis. Participants' HIV testing rates will be monitored by reviewing records before and after the intervention. Researchers will also assess new HIV diagnoses, changes in testing patterns by country and specialty, and healthcare professionals' knowledge and attitudes toward HIV. The study includes ongoing evaluation of how well the teams operate, resource use, and cost-effectiveness. Data collection extends up to several years to observe long-term effects, with continuous monitoring of care access and prevention services.
CONDITIONS
#AWARE.HIV Europe: Supporting Healthcare Professionals to Find Undiagnosed HIV in European Hospitals: An Effectiveness-implementation Trial.
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 year
Participants experience the implementation of a local HIV team in the hospital to support healthcare professionals with activities including audit and feedback, stigma reduction, education, and linkage to prevention and care.
Periodic assessments every 3 months during implementation
Duration - Up to 2 years
Follow-up assessments continue after the initial implementation to monitor ongoing impact and adaptations of the HIV team activities.
Assessments every 6 months during continuation
Total: 28 locations
1
University Hospital Ghent
Ghent, Belgium
Not Yet Recruiting
2
European hospital of Marseille
Marseille, France, 13003
Actively Recruiting
3
St. Joseph Krankenhaus Berlin Tempelhof
Berlin, Germany, 12101
Actively Recruiting
4
Charité Universitätsmedizin Berlin
Berlin, Germany, 13353
Actively Recruiting
5
Cologne University Hospital
Cologne, Germany, 50937
Actively Recruiting
6
Klinikum der Technischen Universität München (TUM)
München, Germany, 81675
Actively Recruiting
7
Ospedale San Raffaele S.r.l
Milan, Italy
Actively Recruiting
8
L'Istituto Nazionale per le Malattie Infettive "L. Spallanzani" IRCCS
Roma, Italy, 00149
Actively Recruiting
9
Rijnstate ziekenhuis
Arnhem, Netherlands
Actively Recruiting
10
Stichting Catharina Ziekenhuis
Eindhoven, Netherlands, 5623EJ
Actively Recruiting
11
University Medical Center Groningen
Groningen, Netherlands, 9713GZ
Actively Recruiting
12
Stichting Maasstad Ziekenhuis
Rotterdam, Netherlands, 3079DZ
Actively Recruiting
13
Haga Ziekenhuis
The Hague, Netherlands
Actively Recruiting
14
SPZZOZ Janów Lubelski
Janów Lubelski, Poland, 23-300
Actively Recruiting
15
Wojewodzki Szpital Zespolony
Kielce, Poland, 25-736
Actively Recruiting
16
Państwowy Instytut Medyczny MSWiA w Warszawie
Warsaw, Poland, 02-507
Actively Recruiting
17
Central Military Emergency University Hospital "Dr. Carol Davila"
Bucharest, Romania, 010825
Actively Recruiting
18
Clinical Emergency Hospital "Prof. Dr. Agrippa Ionescu"
Bucharest, Romania, 011356
Actively Recruiting
19
National Institute for Infectious Diseases "Prof. Dr. Matei Bals"
Bucharest, Romania, 021105
Actively Recruiting
20
Fundeni Clinical institute
Bucharest, Romania, 022328
Actively Recruiting
21
Spitalul Universitar de Urgență București
Bucharest, Romania, 050098
Actively Recruiting
22
Hospital Universitario La Paz-Carlos III
Madrid, Spain, 28029
Actively Recruiting
23
Infanta Leonor
Madrid, Spain
Actively Recruiting
24
La Princesa
Madrid, Spain
Actively Recruiting
25
Central city clinical hospital of Ivano-Frankivsk city council
Ivano-Frankivsk, Ukraine
Actively Recruiting
26
Lviv National Medical University
Lviv, Ukraine, 79010
Actively Recruiting
27
Buckinghamshire Healthcare NHS Trust
Aylesbury, United Kingdom, HP21 8AL
Actively Recruiting
28
Royal Free London
London, United Kingdom, NW3 2QG
Actively Recruiting
K
Klaske J Vliegenthart-Jongbloed, Internist-Infectiologist, DTMH
M
Marianne van Wingerden, Research nurse
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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Carlijn C E Jordans, Klaske Vliegenthart-Jongbloed, Kara K Osbak...
https://pubmed.ncbi.nlm.nih.gov/40053486C C E Jordans, K J Vliegenthart-Jongbloed, A W van Bruggen...
https://pubmed.ncbi.nlm.nih.gov/38869755Klaske J Vliegenthart-Jongbloed, Marta Vasylyev, Carlijn C E Jordans...
https://pubmed.ncbi.nlm.nih.gov/38399659