What is this study trying to find out about HIV infection?

This study is evaluating whether introducing dedicated HIV teams in hospitals can improve HIV testing rates among patients with HIV-related conditions. It aims to see if this approach helps find more undiagnosed HIV cases and supports better care. The study is conducted across multiple European countries to assess how such teams work in different healthcare settings.

Who may be eligible for this HIV clinical trial?

Adults aged 18 years and older treated at hospitals where HIV testing for indicator conditions is routine may be eligible. The hospital must have management support, resources to form an HIV team, IT infrastructure for monitoring, and assure access to HIV care and treatment. This study includes all genders. Please review eligibility criteria for more details.

Is there any cost to participate in this HIV clinical trial?

Study-related care, including the study procedures and all trial visits, is provided at no cost. However, personal travel expenses or other costs may vary and are not guaranteed to be covered. Participants can expect the trial to cover the intervention activities without charge.

Actively Recruiting

Phase Not Applicable

Age: 18Years +

All Genders

Healthy Volunteers

ID06900829

AWARE.HIV Europe Supporting Healthcare Professionals to Find Undiagnosed HIV in European Hospitals - An Effectiveness-Implementation Trial

Led by Casper Rokx · Updated on 2026-03-12

5200

Participants Needed

Research Sites

43 weeks

Total Duration

AI-Summary

What this Trial Is About

This research aims to evaluate whether creating dedicated HIV teams in hospitals across ten European countries can increase HIV testing rates among patients showing signs of HIV-related conditions. The study uses a stepped-wedge design, where hospitals switch from routine care to the new intervention in sequence. This approach compares outcomes before and after the teams are in place, helping to understand the impact of the intervention across various locations and medical specialties. The intervention involves establishing local HIV teams led by specialists and supported by nurses and data experts. These teams identify patients needing HIV tests through electronic health records, provide feedback to doctors to encourage testing, offer education to healthcare staff about HIV, reduce stigma, and improve connections to prevention and care services. This program integrates smoothly into regular hospital routines and aims to close gaps in HIV diagnosis. Participants HIV testing rates will be monitored by reviewing records before and after the intervention. Researchers will also assess new HIV diagnoses, changes in testing patterns by country and specialty, and healthcare professionals knowledge and attitudes toward HIV. The study includes ongoing evaluation of how well the teams operate, resource use, and cost-effectiveness. Data collection extends up to several years to observe long-term effects, with continuous monitoring of care access and prevention services.

CONDITIONS

Brief Title

#AWARE.HIV Europe: Supporting Healthcare Professionals to Find Undiagnosed HIV in European Hospitals: An Effectiveness-implementation Trial.

Who Can Participate

Age: 18Years +

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

HIV testing for indicator conditions is part of routine care in the hospital's country
Hospital management agrees to allocate resources and authorize HIV team activities
Hospital can assemble an HIV team led by a local HIV expert
IT support and infrastructure exist to flag HIV indicator conditions and monitor implementation
Continuous linkage to HIV care and access to antiretroviral therapy is assured
Ethical and regulatory compliance provisions are in place

You will not qualify if you...

Hospitals that do not meet the inclusion criteria are excluded
Data from patients who object to use of their data for research will not be used

Research Team

Klaske J Vliegenthart-Jongbloed, Internist-Infectiologist, DTMH

Marianne van Wingerden, Research nurse

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