Actively Recruiting
AXillary Surgery After NeoAdjuvant Treatment
Led by European Breast Cancer Research Association of Surgical Trialists · Updated on 2025-03-03
3000
Participants Needed
1
Research Sites
517 weeks
Total Duration
On this page
Sponsors
E
European Breast Cancer Research Association of Surgical Trialists
Lead Sponsor
A
AWOgyn
Collaborating Sponsor
AI-Summary
What this Trial Is About
The optimal surgical axillary staging technique in patients who convert from the clinically positive to clinically negative lymph node status under neoadjuvant therapy (cN+ → ycN0) remains to be clarified. Different strategies (axillary lymph node dissection, sentinel node biopsy, targeted axillary dissection) are currently used in different countries. A prospective analysis comparing these techniques regarding feasibility, safety, morbidity and surgical effort is urgently needed. Due to high complexity and discordant recommendations, a randomized trial comparing different techniques is hardly feasible. Therefore, the EUBREAST study group decided to initiate a prospective cohort study as an international project that aims at comparatively evaluating data on axillary staging after neoadjuvant therapy.
CONDITIONS
Official Title
AXillary Surgery After NeoAdjuvant Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent form
- Primary invasive breast cancer confirmed by core biopsy
- Clinically positive lymph nodes (cN+)
- Tumor stage cT1 to cT4c
- Scheduled for neoadjuvant systemic therapy
- Female or male patients aged 18 years or older
You will not qualify if you...
- Presence of distant metastasis
- Recurrent breast cancer
- Inflammatory breast cancer
- Extramammary breast cancer
- Supraclavicular lymph node metastasis
- Pregnancy
- Less than 4 cycles of neoadjuvant chemotherapy administered
- Patients not suitable for surgical treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Klinikum Esslingen
Esslingen am Neckar, Germany
Actively Recruiting
Research Team
T
Thorsten Kühn, Prof.
CONTACT
M
Maggie Banys-Paluchowski, PD Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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