Actively Recruiting
Effects of Single Dose of Ayahuasca or Esketamine on Posttraumatic Stress Disorder: a Randomized, Double-blinded Study
Led by University of Sao Paulo · Updated on 2026-01-05
10
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of a single dose of oral ayahuasca compared to oral esketamine in adults with posttraumatic stress disorder (PTSD). This phase 2, double-blind, randomized clinical trial aims to understand how these treatments impact PTSD symptoms over a short period. Participants will receive either one dose of oral ayahuasca or oral esketamine as part of the study. The trial is designed with two groups: one receiving ayahuasca and the other receiving esketamine, with neither the participants nor the researchers knowing who receives which treatment during the study. Throughout the three-week study, researchers will monitor participants using the Posttraumatic Stress Disorder Checklist for DSM-5 to assess symptom changes. Participants will be followed from enrollment until the end of treatment to evaluate the effects of the treatments on PTSD symptoms.
CONDITIONS
Brief Title
Ayahuasca, Esketamine and PTSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- Diagnosis of posttraumatic stress disorder
You will not qualify if you...
- Presence of psychiatric or other significant medical comorbidities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 weeks
Participants receive a single dose of either oral ayahuasca or oral esketamine to treat posttraumatic stress disorder.
1 baseline visit and regular follow-up visits during treatment
Trial Site Locations
Total: 1 location
1
Hospital das Clínicas da FMRP-USP
Ribeirão Preto, São Paulo, Brazil, 14049900
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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