Actively Recruiting
Study Comparing One Dose of Oral Ayahuasca or Esketamine for Treating Posttraumatic Stress Disorder
Led by University of Sao Paulo · Updated on 2026-01-05
10
Participants Needed
1
Research Sites
4 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of a single dose of oral ayahuasca compared to oral esketamine in adults with posttraumatic stress disorder PTSD. This phase 2, double-blind, randomized clinical trial aims to understand how these treatments impact PTSD symptoms over a short period. Participants will receive either one dose of oral ayahuasca or oral esketamine as part of the study. The trial is designed with two groups one receiving ayahuasca and the other receiving esketamine, with neither the participants nor the researchers knowing who receives which treatment during the study. Throughout the three-week study, researchers will monitor participants using the Posttraumatic Stress Disorder Checklist for DSM-5 to assess symptom changes. Participants will be followed from enrollment until the end of treatment to evaluate the effects of the treatments on PTSD symptoms.
CONDITIONS
Brief Title
Ayahuasca, Esketamine and PTSD
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