Preventing Infections with Azithromycin in Women Undergoing Labor Induction in Their Third Trimester

What this Trial Is About

This research aims to evaluate whether taking 2 grams of oral azithromycin before labor induction in pregnant women during their third trimester can reduce maternal and newborn infections. The trial focuses on women undergoing induction of labor, a common procedure that has increased recently. Researchers want to see if this antibiotic can help prevent infections like chorioamnionitis, endometritis, and wound infections, improving health outcomes and potentially reducing hospital stays and costs. Participants will be randomly assigned to one of two groups one will receive 2 grams of azithromycin four 500 mg tablets once before labor induction, and the other will receive a placebo of four magnesium oxide tablets once before induction. This is a double-blinded study, meaning neither participants nor researchers know who receives the antibiotic or placebo during the trial. Women in the study will be monitored from the time of labor induction through delivery and for six weeks postpartum. Researchers will assess infection rates using a composite infection measure and track any infections that occur during this period. Safety and health outcomes for both mothers and newborns will be carefully followed to understand the impact of azithromycin given before labor induction.

Azithromycin Before Induction