Study on Diagnosis and Follow-up of Patients Suspected of Primary Sjogren Syndrome with Biological and Clinical Assessments

What this Trial Is About

Researchers are evaluating the diagnostic performance of different classification criteria compared to expert doctor diagnosis for primary Sjogren syndrome pSS. This single-center, prospective intervention study aims to improve understanding of pSS diagnosis by collecting standardized biological, clinical, and imaging data from patients suspected of having pSS. Participants include those diagnosed with Sjogren syndrome and those without the diagnosis, grouped accordingly. Sjogren patients will be followed at inclusion, 2, 3, 4, 6, 8, and 10 years, with blood, fluid, cell, and urine samples collected at inclusion, 4, and 10 years. Non-Sjogren controls will be followed at inclusion and 4 years, with sample collection at these visits. Participants will undergo standardized assessments, including sample collection and clinical evaluations over the study period. Researchers will measure the specificity of classification criteria, track disease manifestations using tools like ESSDAI, and evaluate diagnostic performance and disease progression. The study lasts up to 10 years, with periodic follow-up visits and sample collections to monitor disease activity and evolution.

B-dependant Rare AutoImmune diseaSES - Cohort of Patients With Suspected Diagnosis of Primitive Sjögren Syndrome