B-dependant Rare AutoImmune diseases - Cohort of Patients With Suspected Diagnosis of Primary Sjogren Syndrome

What this Trial Is About

Researchers are evaluating the diagnostic accuracy of various classification criteria for primary Sjogren syndrome (pSS) by comparing them to the diagnosis made by expert doctors after a standardized assessment. This single-center, prospective study aims to improve understanding of how well these criteria identify pSS in patients suspected of having this autoimmune condition. Participants suspected of pSS will be divided into two groups: those diagnosed with Sjogren syndrome and those not diagnosed (controls). The study involves collecting standardized biological, clinical, imaging, and pathology data. Blood, fluid, cell, and urine samples will be collected at baseline, 4 years, and 10 years for Sjogren patients, while controls will have follow-up visits and sample collection at baseline and 4 years. Participants will be followed over multiple years with visits at inclusion, 2, 3, 4, 6, 8, and 10 years for the Sjogren group, and at inclusion and 4 years for controls. The study will monitor disease manifestations, diagnostic test performance, and disease evolution using tools such as the ESSDAI index. Safety and diagnostic outcomes will be regularly assessed throughout the study, which lasts up to 10 years.

B-dependant Rare AutoImmune diseaSES - Cohort of Patients With Suspected Diagnosis of Primitive Sjögren Syndrome