Study of B-vitamins and Omega-3 Fatty Acids to Support Brain Health and Slow Brain Aging in Older Adults

What this Trial Is About

Researchers are investigating the combined effects of B-vitamins and omega-3 fatty acids on brain health in older adults. This study focuses on how these supplements may influence brain atrophy by measuring neurofilament light chain NfL, a key biomarker linked to brain inflammation, atrophy, and cognitive decline. The study also explores secondary outcomes including changes in blood markers, gene expression, metabolite profiles, quality of life, and cognitive performance. Participants will be randomly assigned to one of two groups. The intervention group receives daily supplements consisting of one pill of B-vitamins including B12, folate, B6, and riboflavin plus six pills of Lysoveta, a bioavailable omega-3 fatty acid supplement derived from krill. The control group receives matching placebo pills. The study lasts for three months, during which participants take the supplements daily while remaining blinded to their group assignment. Throughout the study, participants will undergo blood tests to measure biomarkers such as NfL, homocysteine, and omega-3 levels, along with assessments of cognitive function and quality of life using standardized questionnaires. These evaluations help researchers understand the effects of the supplements on brain aging and cognitive health. The total participation time covers the three-month supplementation period and associated assessments.

B-vitamins and Omega-3 Fatty Acids and Biomarkers of Brain Atrophy.