Study of Bacillus cereus Infections in Premature Newborns With Sepsis in French Hospitals

What this Trial Is About

Researchers are studying invasive infections caused by Bacillus cereus group bacteria in premature newborns hospitalized in French hospitals. These infections have recently been linked to serious conditions like sepsis and septic shock in preterm neonates, with mortality rates up to 30%. The study aims to identify the specific bacterial species involved and analyze their virulence genes to understand factors linked to poor outcomes. The study uses whole genome sequencing with advanced Illumina and Nanopore technologies to examine bacterial strains isolated from blood and cerebrospinal fluid of affected premature newborns. This observational research focuses on accurately characterizing the bacteria causing infections and their genetic profiles. Participants are premature newborns born before 37 weeks who have invasive infections caused by Bacillus cereus. The study collects clinical data and bacterial genomic information to analyze risk factors for death, with mortality measured up to 28 days after birth. The study is sponsored by Centre Hospitalier Universitaire de Nice and runs through December 2026.

Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals