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Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals
Led by Centre Hospitalier Universitaire de Nice · Updated on 2026-01-28
40
Participants Needed
13
Research Sites
886 weeks
Total Duration
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AI-Summary
What this Trial Is About
Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the mortality rate can reach up to 30%. Using Whole Genome Sequencing (WGS) increasingly used to characterize Bc strains, The team aimed to determine an accurate identification to the species level of the strains involved in Bc invasive infections in preterm neonates in France and study their virulome profile.Methods. The team performed WGS for 40 neonate clinical strains responsible for invasive infections in PN. A screening of virulence genes was performed to characterize strains associated with poor prognosis. Clinical data were collected and all clinical and genomic findings were analyzed for risk factors for death. "
CONDITIONS
Official Title
Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Premature newborn (born before 37 last menstrual periods) with invasive infection caused by B. cereus (strains isolated from blood culture and cerebrospinal fluid)
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 13 locations
1
CHU NICE
Nice, Alpes Maritimes, France, 06000
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2
CHU lille
Lille, France
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3
AP-HM Marseille
Marseille, France
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4
CHU Nantes
Nantes, France
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5
CHU Nîmes
Nîmes, France
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6
AP-HP Hôpital Robert Debré
Paris, France
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7
Hôpital Antoine Béclère, AP-HP
Paris, France
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8
Hôpital Cochin
Paris, France
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9
CHU de Poitiers
Poitiers, France
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10
CHU Rennes
Rennes, France
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11
CHRU de Strasbourg
Strasbourg, France
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12
CHU Toulouse
Toulouse, France
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13
CHU de Tours
Tours, France
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Research Team
R
Raymond Ruimy
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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