Actively Recruiting
Backtracking Leukemia-Typical Somatic Mutations in Cord Blood
Led by Children's Oncology Group · Updated on 2026-04-08
300
Participants Needed
1
Research Sites
266 weeks
Total Duration
On this page
Sponsors
C
Children's Oncology Group
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
A comprehensive mechanistic and epidemiological study to obtain banked cord blood samples from consecutive childhood leukemia patients enrolled in the COG Project:EveryChild (APEC14B1) study. Will attempt to backtrack the initiating genomic alteration identified in the matched diagnostic leukemia sample and molecularly characterize pre-leukemic cells. The ultimate goal of this research is to pinpoint the cell of origin of leukemogenic alterations formed in utero, elucidating the etiology of these initiating mutations (as opposed to frank leukemia), and devising a test for circulating pre-leukemia that can be applied on a population-wide basis.
CONDITIONS
Official Title
Backtracking Leukemia-Typical Somatic Mutations in Cord Blood
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML)
- Availability of stored diagnostic pre-treatment leukemia samples from COG Biopathology Center or treating institution
- Enrollment in APEC14B1 with consent for future contact and indication of stored cord blood at birth
- Registered with a North American member institution (U.S. or Canada)
- Age 25 years or younger at original leukemia diagnosis
- Ability to understand written and spoken English or Spanish
- Consent/assent provided by patient and parent or legal guardian if under age of majority
- Compliance with all institutional, FDA, and NCI requirements for human studies
You will not qualify if you...
- No stored cord blood at birth
- No stored diagnostic pre-treatment leukemia samples available from COG Biopathology Center or treating institution
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
A
Adam de Smith, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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