Actively Recruiting
Bacterial Interference for Preventing Recurrent Urinary Tract Infection - New Ways of Treatment
Led by Odense University Hospital · Updated on 2025-09-18
80
Participants Needed
2
Research Sites
203 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Urinary tract infection (UTI) is one of the most common bacterial infections worldwide. It affects 150 million people annually. Treatment of patients with UTI entails a high consumption of antibiotics and large social and health costs. With this protocol, we want to elucidate alternative treatment methods for especially recurrent urinary tract infection. Bacteria have internal competitiveness (bacterial interference) and it is known that the non-pathogenic E.coli can outcompete the pathogenic E.coli in laboratory studies. We intend to strengthen the clinical evidence that it can be used as patient treatment through a clinical, placebo-controlled, double-blind trial at Odense University Hospital.
CONDITIONS
Official Title
Bacterial Interference for Preventing Recurrent Urinary Tract Infection - New Ways of Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with recurrent cystitis including 2 times of recurrent urinary tract infection within the last 6 months or 3 times in the last 12 months, where at least 2 cultures show the same bacteria.
- Normal investigation for lower urinary tract diseases including voiding diary, symptom scores, flexible cystoscopy, voiding diagram and test for residual urine.
- Failed previous treatments.
- Patients with native bladder with spontaneous voiding, need for clean intermittent catheterization, or indwelling catheter.
- Patients with neurogenic and non-neurogenic bladder dysfunction.
- Patients with urostomy, kidney transplantation, or other complicated origins.
- Written consent provided.
You will not qualify if you...
- Malignancy in the urinary tract.
- Kidney, ureteral, or bladder stones.
- Age under 18 years.
- Pregnancy or breastfeeding.
- Current oral antibiotic treatment.
- Unable to speak or understand Danish.
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Aarhus University Hospital
Aarhus N, Denmark, 8200
Actively Recruiting
2
Odense University Hospital
Odense C, Denmark, 5000
Actively Recruiting
Research Team
K
Karin Andersen, MD
CONTACT
L
Lars Lund, Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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