Actively Recruiting
Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
Led by Abhishek Parolia · Updated on 2025-09-17
90
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.
CONDITIONS
Official Title
Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of pulp necrosis with apical periodontitis confirmed by pulp tests, clinical and radiographic evidence
- Tooth with no response to cold and electric pulp testing (done at screening)
- Single canalled premolars with intact pulp chamber walls
- Patient must be 18 years of age or older
You will not qualify if you...
- Teeth with vital pulp
- Teeth with incomplete root formation (immature with apical periodontitis)
- Teeth with extensive crown destruction
- Teeth with previous endodontic treatment or intervention (pulp debridement)
- Teeth with acute/ chronic apical abscess
- Teeth with internal or external resorption
- Teeth with non-odontogenic facial pain
- Teeth with periodontal pockets deeper than 4 mm
- Teeth with advanced untreated periodontal disease or recent periodontal surgery
- Teeth with mobility score greater than 2
- Teeth with a fracture or visible crack
- Patients with diabetes or immune compromised conditions
- Patients who received systemic antibiotics within the last 3 months
- Patients taking corticosteroids
- Patients who are pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa College of Dentistry and Dental Clinics
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
A
Abhishek Parolia, PhD, MDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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