Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID03881930

Balance Rehabilitation With Modified Visual Input in Patients With Acquired Chronic Demyelinating Neuropathy and Proprioceptive Disorders

Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-05-27

40

Participants Needed

1

Research Sites

21 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research investigates balance rehabilitation in patients with acquired chronic demyelinating neuropathy who experience walking instability due to sensitivity disorders. The study aims to evaluate how modifying visual input during rehabilitation might reduce visual dependence and strengthen proprioceptive input, potentially improving balance and walking ability in these patients. This multicenter study is conducted in the Paris area and plans to include 40 participants. Participants are randomly assigned to one of two groups. The experimental group undergoes 20 rehabilitation sessions with a Physical Therapist, performing balance exercises while keeping their eyes closed or with vision obstructed or disturbed by visual effects in a dark room. The control group also receives 20 rehabilitation sessions but performs balance exercises with their eyes open and no visual modification. Both groups have three assessments during the study. Participants will undergo evaluations including timed U-turns at comfortable and fast speeds, number of steps, double stance phase while walking, global movement amounts, walking times and steps over 10 meters, various sensory and balance tests, and balance confidence scales. Assessments occur just after rehabilitation completion and again two months later. The primary outcome is the U-turn completion time measured shortly after the last session. The rehabilitation program spans 20 sessions with follow-up evaluations up to two months post-treatment.

CONDITIONS

Brief Title

Balance Rehabilitation With Modified Visual Input in Patients With Neuropathy

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients with chronic demyelinating acquired neuropathy
  • Age 18 years or older
  • Able to walk 20 meters indoors without human assistance, with or without technical help
  • Complaints of discomfort or walking instability related to sensitivity disorders
  • Clinically stable for at least 2 months regardless of current treatments
  • Provided informed consent to participate
Not Eligible

You will not qualify if you...

  • Unable to walk 20 meters indoors without technical and human assistance
  • Currently hospitalized
  • Already participating in another intervention study
  • Undergoing ongoing balance rehabilitation in another center or practice
  • Started or stopped acute treatment related to polyneuropathy less than 2 months ago
  • Scheduled surgery during participation that prevents completing rehabilitation and assessments
  • Recent surgery, especially lower limb prosthesis less than 1 year old or contraindicated equipment
  • Skin wounds on the foot that prevent rehabilitation
  • Balance disorders of vestibular or central neurological origin
  • Visual disability
  • Hearing impairment preventing understanding instructions
  • Inability to speak or understand French
  • Cognitive or language impairments preventing understanding the protocol
  • Residence outside the Paris Region (Ile de France)
  • Known pregnancy
  • Not affiliated with a social security system, under guardianship, curatorship, or prisoner

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 20 sessions over several weeks

Participants perform 20 rehabilitation sessions with a Physical Therapist. The experimental group will do balance training with modified visual input, while the control group performs balance training with no modified visual input.

20 rehabilitation sessions

Follow-up

Duration - Up to 2 months after treatment

Participants undergo assessments to evaluate balance and walking ability just after the rehabilitation program and again 2 months later.

3 assessment visits (shortly after treatment and at 2 months post-treatment)

Trial Site Locations

Total: 1 location

1

Service de Médecine Physique et de Réadaptation (MPR)

Paris, France, 75010

Actively Recruiting

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Research Team

B

Bénédicte PANIGOT GUERIN, PT

A

Alain YELNIK, MD, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

Observational Study of 180° Turning Strategies Using Inertial Measurement Units and Fall Risk in Poststroke Hemiparetic Patients.

Rémi Pierre-Marie Barrois, Damien Ricard, Laurent Oudre...

https://pubmed.ncbi.nlm.nih.gov/28555124

Reliance on visual information after stroke. Part II: Effectiveness of a balance rehabilitation program with visual cue deprivation after stroke: a randomized controlled trial.

Isabelle V Bonan, Alain P Yelnik, Florence M Colle...

https://pubmed.ncbi.nlm.nih.gov/14966713

Rehabilitation of balance after stroke with multisensorial training: a single-blind randomized controlled study.

Alain P Yelnik, Frederique Le Breton, Florence M Colle...

https://pubmed.ncbi.nlm.nih.gov/18780882

Standing postural reaction to visual and proprioceptive stimulation in chronic acquired demyelinating polyneuropathy.

Clement P Provost, Sophie Tasseel-Ponche, Pierre Lozeron...

https://pubmed.ncbi.nlm.nih.gov/29313871

Evidence of the psychometric qualities of a simplified version of the Activities-specific Balance Confidence scale for community-dwelling seniors.

Johanne Filiatrault, Lise Gauvin, Michel Fournier...

https://pubmed.ncbi.nlm.nih.gov/17466738