Actively Recruiting
Bariatric Surgery Combined With GLP-1 Receptor Agonists Study
Led by China-Japan Friendship Hospital · Updated on 2026-04-23
200
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obese patients exhibit considerable heterogeneity and complex comorbidities, making long-term effective management challenging with single therapies. While bariatric surgery remains the most effective weight-loss intervention, postoperative weight regain and metabolic deterioration require attention. GLP-1 RAs offer distinct advantages for weight and metabolic improvement, and their combined application with surgery may yield synergistic benefits. This study investigates the efficacy and safety of bariatric surgery combined with GLP-1 receptor agonist adjuvant therapy for severe obesity.
CONDITIONS
Official Title
Bariatric Surgery Combined With GLP-1 Receptor Agonists Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing their first laparoscopic sleeve gastrectomy (primary metabolic surgery candidates)
- Body mass index (BMI) of 35 kg/m² or greater
- Diagnosis of metabolic syndrome or type 2 diabetes mellitus according to standard criteria
- Age between 18 and 60 years inclusive
- Willing to participate and provide documented informed consent
You will not qualify if you...
- Treatment with GLP-1 receptor agonists within 6 months before surgery
- History of any metabolic or bariatric surgery
- Postoperative complications requiring reoperation, such as hemorrhage or anastomotic leak
- Not meeting standard indications for bariatric surgery
- Advanced liver or kidney problems (Child-Pugh C liver disease or kidney function below eGFR 30 mL/min/1.73m²)
- Active cancer except for non-melanoma skin cancers
- Autoimmune diseases needing immunosuppressive treatment
- Uncontrolled psychiatric conditions like active psychosis or severe depression
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
China-Japan Friendship Hospital
Beijing, China
Actively Recruiting
Research Team
Y
Yishan Huang, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here