Actively Recruiting
Bariatric Surgery for the Reduction of cArdioVascular Events Randomized Controlled Trial
Led by Population Health Research Institute · Updated on 2026-02-23
200
Participants Needed
1
Research Sites
347 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this study is to evaluate if, in patients with severe obesity (body mass index (BMI) ≥30 kg/m2) and high-risk cardiovascular disease (CVD), bariatric surgery compared to medical weight management (MWM) safely reduces the risk of major cardiovascular events. The cost-effectiveness of bariatric surgery will also be examined. Separate sub-studies will be performed to examine the relationship between bariatric surgery and mental health, cardiac structure and function, genomics, proteomics and metabolomics.
CONDITIONS
Official Title
Bariatric Surgery for the Reduction of cArdioVascular Events Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index (BMI) of 30 kg/m2 or higher; OR BMI 30 to 34.9 kg/m2 with type 2 diabetes or age over 55 years
- Age 18 years or older
- High-risk cardiovascular disease, defined by any of the following: history of major coronary artery disease, left ventricular ejection fraction below 40%, heart failure with preserved ejection fraction and recent hospitalization or elevated heart failure markers, documented atrial fibrillation with stroke risk score of 2 or higher, history of any stroke, or documented peripheral arterial disease
You will not qualify if you...
- Hospital admission for heart failure, myocardial infarction, stroke, or coronary revascularization within 30 days before randomization
- Percutaneous coronary intervention with a drug-eluting stent within 90 days before randomization
- Pregnancy
- Contraindication to bariatric surgery
- Prior bariatric surgery except gastric banding
- Life expectancy less than 2 years due to non-cardiovascular causes
- Inability to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hamilton Health Sciences
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
Research Team
J
Jorge Wong, MD, MPH, FRCPC
CONTACT
S
Sumathy Rangarajan, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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