Study of How Daily Rhythms and Exercise Timing Affect Muscle Metabolism in Healthy Adults Aged 18 to 50

What this Trial Is About

Researchers are studying how the bodys internal clock controls daily rhythms in metabolism, particularly focusing on human skeletal muscle. This research aims to understand how muscle activity and timing of exercise affect metabolism over a 24-hour period, building on previous findings from rodent studies and initial human muscle sampling. The study is led by the University of Bath and explores links between muscle metabolism, nutrient availability, and daily biological rhythms. Participants will be randomly assigned to one of three groups early exercise, late exercise, or resting control. Those in exercise groups will perform one hour of cycling either at 800 AM or 800 PM during a 24-hour monitoring period. Nutrients will be continuously delivered through a nasogastric tube throughout the day and night. Muscle and blood samples will be collected multiple times during the 24-hour period, with participants staying in the lab for 36 hours including overnight monitoring. Before the main study visit, participants will undergo preliminary testing and follow controlled diet and activity patterns for a week. During the study, resting metabolic rate, body temperature, and glucose levels will be monitored using various devices. Researchers will measure carbohydrate metabolism, muscle protein synthesis, gene expression, blood hormone levels, and other metabolic markers. The goal is to capture detailed metabolic rhythms and how they change with exercise timing over the 24-hour cycle.

Bath Myorhythms Project