Actively Recruiting
Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE
Led by M.D. Anderson Cancer Center · Updated on 2026-01-26
100
Participants Needed
1
Research Sites
197 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical research study is to learn more about whether individual differences in brain responses to emotional triggers impact rTMS (repetitive transcranial magnetic stimulation) responses in people who smoke.
CONDITIONS
Official Title
Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21 to 60 years
- Smoking an average of 5 or more cigarettes, little cigars, or cigarillos daily within the past 30 days
- Expired carbon monoxide (CO) level of 6 ppm or higher and/or positive urine cotinine test on study visit day
- Ability to understand and follow verbal and written instructions in English
- Have a reachable address and telephone number
- Stable residence not including shelters, halfway houses, treatment centers, or group homes
- Meet safety criteria for EEG
- Willingness to vape from an e-cigarette during specific tasks
- Meet safety criteria for rTMS or willing to complete EEG portion if not eligible for rTMS
- Willing and able to remove metal from the neck and above for rTMS procedures
- Provide written informed consent and agree to all study procedures
- Agree to complete telehealth and in-person visits and be contacted via text
You will not qualify if you...
- rTMS treatment or research exposure within the last 6 months
- History of seizure, epilepsy, fainting episodes, or head trauma causing loss of consciousness
- Presence or history of neurological disorders such as migraine, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, traumatic brain injury, or increased intracranial pressure
- History of brain surgery, implanted electronic devices, or metal in the head
- Cardiac pacemakers, neural stimulators, implantable defibrillators, medication pumps, intracardiac lines, or unstable cardiac disease
- History or current care for myocardial infarction, angina, heart failure, cardiomyopathy, stroke, or transient ischemic attack
- Untreated vision problems
- Hairstyles incompatible with EEG net and unwillingness to modify hairstyle
- Current or history of type I diabetes
- Current insulin use
- History of bariatric surgery
- Enrollment in a weight loss program
- Use of medications or supplements to control weight or appetite
- History or current diagnosis of mental health conditions
- Insomnia defined as less than 4 hours of sleep at least 3 nights per week in the past 3 months
- Less than 4 hours of sleep on the day of the visit
- Daily marijuana use
- Use of illicit drugs (other than marijuana) or prescription drugs for non-medical reasons in the past 12 months
- Current treatment for substance use disorder
- Excessive alcohol consumption (females >7 drinks/week, males >14 drinks/week) in the past 30 days
- Use of investigational drugs, anti/pro-convulsive drugs, psychotropic medications, seizure risk medications, smoking cessation drugs, or nicotine replacement therapy in the past 3 months
- Pregnancy or lactation
- Self-reported noise-induced hearing loss or tinnitus
- Participation in another research study
- Any medical or psychiatric condition or medication that could compromise safety or treatment as determined by the study physician
- Any other reasons deemed unsuitable by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas M. D. Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
F
Francesco Versace, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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