Actively Recruiting

Phase 3
Age: 18Years - 75Years
All Genders
NCT07168161

BDB-001 Phase III Trial in ANCA-Associated Vasculitis

Led by Staidson (Beijing) Biopharmaceuticals Co., Ltd · Updated on 2026-04-23

300

Participants Needed

60

Research Sites

120 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The primary aim is to study the efficacy of treatment with BDB-001 Injection to induce remission in patients with active anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), when used in combination with cyclophosphamide followed by azathioprine, or in combination with rituximab

CONDITIONS

Official Title

BDB-001 Phase III Trial in ANCA-Associated Vasculitis

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 75 years, male or female
  • Diagnosed with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA)
  • Newly diagnosed or relapsed GPA or MPA requiring treatment with full starting dose prednisone plus cyclophosphamide/azathioprine or rituximab
  • Positive test for anti-proteinase 3 (PR3) or anti-myeloperoxidase (MPO)
  • Estimated glomerular filtration rate (eGFR) of at least 15 mL/min/1.73 m²
  • Presence of at least 1 major item, or at least 3 non-major items, or at least the 2 renal items on Birmingham Vasculitis Activity Score (BVAS)
Not Eligible

You will not qualify if you...

  • Active tuberculosis infection
  • Alveolar hemorrhage requiring pulmonary ventilation support
  • History of any malignancy within 5 years except completely resected basal cell carcinoma or carcinoma in situ without recurrence or metastasis
  • Other known multi-system autoimmune diseases including eosinophilic granulomatosis with polyangiitis, systemic lupus erythematosus, IgA vasculitis, rheumatoid vasculitis, anti-glomerular basement membrane disease, or cryoglobulinemic vasculitis
  • Positive hepatitis B surface antigen or positive hepatitis B core antibody with detectable HBV-DNA
  • Received cyclophosphamide within 3 months or rituximab/B-cell antibodies within 12 months before first dose
  • Received glucocorticoid shock therapy within 4 weeks before first dose
  • Taken daily oral prednisone equivalent over 10 mg for more than 6 weeks before first dose
  • Received anti-tumor necrosis factor or other biological treatments within 12 weeks before first dose
  • Received continuous dialysis for 12 weeks or more or dialysis within 1 week before first dose
  • Received intravenous immunoglobulin or plasma exchange within 4 weeks before first dose
  • Pregnant or lactating

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 60 locations

1

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China, 100005

Not Yet Recruiting

2

Peking University People's Hospital

Beijing, Beijing Municipality, China, 100044

Not Yet Recruiting

3

Peking University Third Hospital

Beijing, Beijing Municipality, China, 100191

Not Yet Recruiting

4

Peking University International Hospital

Beijing, Beijing Municipality, China, 102206

Not Yet Recruiting

5

Beijing Tsinghua Changgung Hospital

Beijing, Beijing Municipality, China, 102218

Not Yet Recruiting

6

Peking University First Hospital

Beijing, Beijing Municipality, China, 710000

Not Yet Recruiting

7

The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China, 400010

Not Yet Recruiting

8

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China, 400016

Not Yet Recruiting

9

The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China, 361003

Not Yet Recruiting

10

The First Hospital of Lanzhou University

Lanzhou, Gansu, China, 730000

Not Yet Recruiting

11

Guangdong General Hospital

Guangzhou, Guangdong, China, 510080

Not Yet Recruiting

12

Sun Yat-sen Memorial Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China, 510120

Not Yet Recruiting

13

Meizhou People's Hospital

Meizhou, Guangdong, China, 514031

Not Yet Recruiting

14

Yuebei People's Hospital

Shaoguan, Guangdong, China, 512026

Not Yet Recruiting

15

Guangdong Provincial People's Hospital

Shenzhen, Guangdong, China, 510080

Not Yet Recruiting

16

Peking university Shenzhen Hospital

Shenzhen, Guangdong, China, 518036

Not Yet Recruiting

17

Liuzhou People's Hospital

Liuzhou, Guangxi, China, 545006

Not Yet Recruiting

18

The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China, 530021

Not Yet Recruiting

19

Guangxi Academy of Medical Sciences,The People's Hospital of Guangxi Zhuang Autonomous Region

Nanning, Guangxi Zhuang Autonomous Region (gzar), China, 530016

Not Yet Recruiting

20

Guizhou Provincial People's Hospital

Guiyang, Guizhou, China, 550002

Not Yet Recruiting

21

Cangzhou City People's Hospital

Cangzhou, Hebei, China, 061000

Not Yet Recruiting

22

The Second Hospital of Hebei Medical University City:Shijiazhuang

Shijiazhuang, Hebei, China, 050004

Not Yet Recruiting

23

Kailuan General Hospital

Tangshan, Hebei, China, 063000

Not Yet Recruiting

24

The Second Affiliated Hospital of Harbin

Harbin, Heilongjiang, China, 150086

Not Yet Recruiting

25

The First Affiliated Hospital of Henan University of science and Technology

Luoyang, Henan, China, 471003

Not Yet Recruiting

26

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China, 450052

Not Yet Recruiting

27

Tongji Hospital,Tongji Medical college of Hust

Wuhan, Hubei, China, 100005

Not Yet Recruiting

28

Yichang Central People's Hospital

Yichang, Hubei, China, 443003

Not Yet Recruiting

29

General Hospital of Hunan University of Medicine

Changde, Hunan, China, 415000

Not Yet Recruiting

30

Hunan Provincial People's Hospital

Changsha, Hunan, China, 410005

Actively Recruiting

31

Xiangya Hospital Central South University (Nephrology Department)

Changsha, Hunan, China, 410008

Not Yet Recruiting

32

Xiangya Hospital Central South University(Rheumatism Immunity Branch)

Changsha, Hunan, China, 410008

Not Yet Recruiting

33

General Hospital of Hunan University of Medicine

Huaihua, Hunan, China, 418000

Not Yet Recruiting

34

Zhuzhou Central Hospital

Zhuzhou, Hunan, China, 412007

Not Yet Recruiting

35

Nanjing Gulou Hospital

Nanjing, Jiangsu, China, 210000

Not Yet Recruiting

36

Nanjing University School of Medicine Affiliated Gulou Hospital

Nanjing, Jiangsu, China, 210000

Not Yet Recruiting

37

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China, 221002

Not Yet Recruiting

38

Jiangxi Provincial People's Hospital

Nanchang, Jiangxi, China, 330006

Not Yet Recruiting

39

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China, 330006

Not Yet Recruiting

40

The Second Hospital of Jilin University

Changchun, Jilin, China, 130041

Not Yet Recruiting

41

Affiliated Hospital of Yanbian University (Yanbian Hospital)

Yanbian, Jilin, China, 133000

Not Yet Recruiting

42

Shengjing Hospital of China Medical University

Shengyang, Liaoning, China, 110004

Not Yet Recruiting

43

Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Neimenggu, China, 010050

Not Yet Recruiting

44

Shandong Provincial Hospital

Jinan, Shandong, China, 250021

Not Yet Recruiting

45

Weifang People's Hospital

Weifang, Shandong, China, 261041

Not Yet Recruiting

46

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, China, 200025

Not Yet Recruiting

47

Zhongshan hospital,Fudan University

Shanghai, Shanghai Municipality, China, 200032

Not Yet Recruiting

48

Shanxi Bethune Hospital

Taiyuan, Shanxi, China, 030032

Not Yet Recruiting

49

The Second Hospital of Shanxi Medical University

Taiyuan, Shanxi, China, 030032

Not Yet Recruiting

50

Xijing Hospital

Xi’an, Shanxi, China, 710032

Not Yet Recruiting

51

The First Affiliated Hospital of Xi'an Jiao Tong University

Xi’an, Shanxi, China, 710061

Not Yet Recruiting

52

West China Hospital of Sichuan University

Chengdu, Sichuan, China, 610041

Not Yet Recruiting

53

Sichuan Provincial People's Hospital

Chengdu, Sichuan, China, 610072

Not Yet Recruiting

54

The First Affiliated Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, China, 830054

Not Yet Recruiting

55

The First People's Hospital of Yunnan Province

Kunming, Yunnan, China, 650032

Not Yet Recruiting

56

The First Affiliated Hospital, College of Medicine, Zhejiang University

Hangzhou, Zhejiang, China, 310003

Not Yet Recruiting

57

The Second Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China, 310009

Not Yet Recruiting

58

Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China, 310014

Not Yet Recruiting

59

People's Hospital of Lishui

Lishui, Zhejiang, China, 323000

Not Yet Recruiting

60

The Affiliated Hospital of the Medical School of Ningbo University

Ningbo, Zhejiang, China, 315010

Not Yet Recruiting

Loading map...

Research Team

A

Aiping Sun

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here