Pilot Study of Bariatric Endoscopic Antral Myotomy BEAM for Weight Loss in Adults with Obesity

What this Trial Is About

Researchers are evaluating bariatric endoscopic antral myotomy BEAM, a new endoscopic technique for weight loss in obese patients eligible for endoscopic bariatric therapies. BEAM involves cutting muscle fibers in the gastric antrum to weaken the antral pump, delay gastric emptying, and help induce feelings of fullness. This pilot study aims to investigate the safety and effectiveness of BEAM, which may offer benefits such as lower risks, improved durability, and the ability to assess the stomach lining, which is important in regions with higher rates of gastric intestinal metaplasia or cancers. The procedure is performed using a gastroscope under general anesthesia. A mucosal incision is made at the incisura, followed by submucosal tunneling and partial thickness myotomy at the antrum near the pylorus, finishing with closure of the incision using endoclips. This intervention is studied as a single experimental arm. Participants will undergo the BEAM procedure, which is carefully monitored for technical success and safety. Participants will be followed over time with assessments at baseline and multiple points up to 12 months after the procedure. Measurements include body weight, adverse events within 30 days, blood tests including ghrelin, glucose, insulin, lipid profile, liver parameters, quality of life, gastric emptying symptoms, blood pressure, and sleep apnea. Pain is assessed 3 days post-procedure. This comprehensive follow-up aims to evaluate both the effectiveness and safety of BEAM over one year.

BEAM for Weight Loss - a Pilot Study