Tele-Delivered Behavioral Activation to Prevent Post-Stroke Depression in Low-Income Older Adults with Mild Depressive Symptoms
Led by The University of Texas Health Science Center, Houston · Updated on 2026-04-28
350
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of tele-delivered behavioral activation Tele-BA-S by trained lay counselors to prevent post-stroke depression PSD in low-income, older stroke survivors who have mild or no depressive symptoms subthreshold depression. The study focuses on individuals who have experienced their first ischemic or hemorrhagic stroke within three months and aims to address mental health challenges after stroke in this vulnerable population.
Participants are randomly assigned to either the Tele-BA-S intervention or treatment as usual. The Tele-BA-S group receives five weekly video-conferenced behavioral activation sessions from trained lay counselors, along with homework and two monthly follow-up booster calls. Both groups receive standard hospital discharge educational materials and scheduled follow-up appointments with stroke practitioners at 7-14 days and three months post-stroke, conducted either by video or in person according to patient preference.
During the study, participants will be assessed at multiple time points up to nine months for depression using the Hamilton Depression Rating Scale and Patient Health Questionnaire, as well as for anxiety, emotional distress, quality of life, emergency room visits, hospitalizations, disability, medication adherence, rehabilitation adherence, and daily activities. These assessments will help researchers understand the impact of the tele-delivered behavioral activation on various aspects of health and recovery after stroke.
CONDITIONS
Brief Title
Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors
Research Team
J
Jennifer Beauchamp, PhD, RN
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match. Sign up to get personalized trial recommendations delivered to your inbox.
The University of Texas Health Science Center, Houston
Lead Sponsor
National Institute of Mental Health (NIMH)
Collaborating Sponsor
How This Trial Compares With Other Options
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
Factors
Tele-delivered Behavioral Activation by Lay Counselors
Standard Discharge Education & Follow-up
What it is
A behavioral activation program delivered in five weekly video sessions by trained lay counselors, plus two monthly booster calls and usual post-stroke educational and medical care.
Current standard of care after stroke, including hospital discharge education materials and scheduled follow-up appointments with stroke practitioners.
Role in trial
Investigational intervention designed to prevent post-stroke depression for eligible older stroke survivors with subthreshold depression.
Control arm representing the current standard approach to post-stroke care without added behavioral activation.
Primary use
To prevent the development of post-stroke depression or worsening of subthreshold depression in low-income older adults after stroke.
To provide the standard of care for post-stroke patients, including education and routine follow-up, without extra behavioral activation.
How it is given or performed
Delivered as five weekly video conference sessions by lay counselors, including homework and two monthly booster calls, in addition to receiving the standard discharge packet and scheduled clinical follow-up.
Participants receive educational materials at hospital discharge and attend scheduled video or in-person follow-up appointments according to standard care protocols.
Evidence status
Effectiveness for preventing post-stroke depression is currently under investigation, with no trial results published yet.
Standard discharge education and scheduled follow-up are the current recommended practices, but may not address mild depressive symptoms proactively.
Important limitations
As an investigational approach, outcomes and real-world effectiveness remain unproven, and results will depend on participant engagement with the video-call format.
Standard care does not include dedicated behavioral activation, which may mean less structured support for individuals at risk for depression.
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
Who Can Participate
Age: 55Years +
All Genders
Eligibility Criteria
You may qualify if you...
Enrollment within 3 months plus 2 weeks of a first-time ischemic or hemorrhagic stroke
24-item Hamilton Depression Rating Scale score less than 15 indicating mild or no depression
Single-person income of $45,000 or less
Living in a community residence
Ability to speak and read English or Spanish
Mini-MoCA score of 11 or higher
You will not qualify if you...
Stroke caused by factors unrelated to vascular risk (e.g., drug use) or transient ischemic attack
24-item Hamilton Depression Rating Scale score 15 or higher indicating moderate to severe depression
Currently participating in psychotherapy
High suicide risk or severe psychiatric illness, including bipolar disorder or active psychosis, or taking antipsychotics
Diagnosed dementia or taking cognitive enhancers, amyloid-targeting drugs, or orexin receptor antagonists
Patient Health Questionnaire 9 score 10 or higher or positive answer to question 9
Diagnosed aphasia or severe cognitive impairments
High-risk alcohol or drug misuse
Receiving medications for mood disorders with dose or type changes in the last 4 weeks
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or virtual) for eligibility assessment
Outpatient Treatment
Duration - Approximately 3 months
Participants receive 5 weekly video-conferenced behavioral activation sessions by trained lay counselors, followed by 2 monthly booster calls. All participants also receive standard hospital discharge education and scheduled follow-up appointments with a stroke practitioner.
5 weekly video sessions and 2 monthly booster calls, plus follow-up appointments at 7-14 days and 3 months post-stroke (in-person or video)
Follow-up Monitoring
Duration - 9 months
Participants are monitored for depression symptoms, anxiety, emotional distress, quality of life, hospitalizations, and rehabilitation adherence over 9 months post-baseline.
Assessments at baseline, 1 month, 2 months, 4 months, 6 months, and 9 months
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Similar Trials
Pilot Study of Internet-Delivered Skills Training to Prevent Depression in Adults with Childhood Trauma and Mild Depression
Tele-Delivered Behavioral Activation to Prevent Post-Stroke Depression in Low-Income Older Adults with Mild Depressive Symptoms
Study to Develop and Validate a Model Predicting Depression After Ischemic Stroke Using Patient Data and Machine Learning
Study of Auricular Acupuncture for Treating Insomnia After Stroke and Its Safety
Modified Cardiac Rehabilitation Program to Improve Physical and Mental Health in Adults with Chronic Stroke and Depression
Personalized and Conventional Transcranial Direct Current Stimulation to Improve Loneliness and Mood in Adults with Subthreshold Depression
Transcranial Direct Current Stimulation to Reduce Subthreshold Depressive Symptoms in Young People Aged 12 to 25
Studying How Transcranial Direct Current Stimulation tDCS Helps Improve Emotional Health in Young Adults With Mild Depression
Have more questions? Get in touch with our team for quick support
Published Research Related To This Trial
Behavioural activation for the prevention of poststroke depression in low-income older stroke survivors (LIVE WEL): protocol for a randomised controlled trial.
Jennifer E S Beauchamp, Sean I Savitz, Anjail Sharrief...