Actively Recruiting
Behavioral and Neural Characteristics of Adaptive Speech Motor Control
Led by University of Washington · Updated on 2023-12-11
507
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Washington
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how hearing our own speech influences the planning and execution of speaking movements. This study includes both typical speakers and patients with Deep Brain Stimulation (DBS) implants. It aims to understand whether the way we hear ourselves affects future speech and which brain areas contribute to adjusting speech movements, especially in DBS patients. The study involves manipulating real-time auditory feedback during speech using devices like digital vocal processors or software, as well as altering visual feedback during upper limb reaching movements with a virtual reality system. For DBS patients, the intervention includes switching their brain stimulator ON and OFF while performing speech tasks. These interventions help explore the role of sensory feedback and brain stimulation in speech and movement control. Participants will read words, sentences, or random syllables while their speech is recorded, and some will wear an electrode cap to record brain activity. DBS patients perform tasks with stimulator ON and OFF. Measurements include speech sounds, arm movement directions, brain electrical responses, and accuracy and timing of speech sequences. Each data session lasts from about half an hour to two hours. The study provides insight into brain and speech motor control with no treatment involved.
CONDITIONS
Brief Title
Behavioral and Neural Characteristics of Adaptive Speech Motor Control
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Native speaker of American English
- No communication or neurological problems (except DBS patients)
- Hearing thresholds equal to or better than 25 dB HL for children and young adults or 35 dB HL for older adults
- No medications affecting sensorimotor functioning (except DBS patients)
- Adults 18 years or older
- Typical children aged 4 years 0 months to 6 years 11 months or 10 years 0 months to 12 years 11 months
- Children must score above the 20th percentile on specific vocabulary and language tests (PPVT-5, EVT-3, GFTA-3, TELD-4 or CELF-5 for children 8 or older)
- DBS patients must have bilateral electrodes implanted in the ventral intermediate nucleus of the thalamus or subthalamic nucleus
You will not qualify if you...
- Non-native speakers of American English
- Communication or neurological problems (except DBS patients)
- Hearing thresholds worse than 25 dB HL for children and young adults or worse than 35 dB HL for older adults
- Taking medications that affect sensorimotor functioning (except DBS patients)
- Children outside specified age ranges
- Children scoring below the 20th percentile on required language and vocabulary tests
- DBS patients without bilateral electrodes implanted in specified brain areas
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 to 2 hours per test session
Participants undergo behavioral interventions involving real-time manipulation of auditory feedback during speech production and visual feedback during upper limb reaching movements. Participants with DBS implants toggle stimulation ON/OFF prior to speech motor learning tasks.
1 to 2 in-person sessions depending on intervention assigned
Trial Site Locations
Total: 1 location
1
University of Washington
Seattle, Washington, United States, 98105
Actively Recruiting
Research Team
L
Ludo Max
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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