Actively Recruiting
Behavioral Pharmacology of Orally Administered THC and D-limonene
Led by Johns Hopkins University · Updated on 2025-05-16
65
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The current clinical trial will investigate the effects of orally administered d-limonene (limonene), delta-9-tetrahydrocannabinol (THC) and the combination in healthy adult volunteers.
CONDITIONS
Official Title
Behavioral Pharmacology of Orally Administered THC and D-limonene
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provided written informed consent
- Aged between 21 and 55 years
- In good general health based on physical exam, medical history, vital signs, and screening urine and blood tests
- Negative drug tests for substances other than cannabis, including breath alcohol, at screening and clinic admission
- Not pregnant or nursing if female, with negative pregnancy tests at screening and admission
- Body mass index between 18 and 36 kg/m2
- Blood pressure at screening with systolic ≤150 mmHg and diastolic ≤90 mmHg
- No allergies to cellulose, THC, or d-limonene
- Used a high THC cannabis product in the past 3 years and experienced anxiety after cannabis at least once
You will not qualify if you...
- Non-medical use of psychoactive drugs other than nicotine, alcohol, or caffeine within 3 months prior to screening
- History or current evidence of significant medical conditions (e.g., seizure disorder) or psychiatric illness (e.g., psychosis) increasing risk of adverse events
- Use of prescription medications (except birth control), OTC drugs, herbal supplements, or vitamins within 14 days before experimental sessions if interfering with study safety or results
- Cannabis use averaging more than twice per week in past 3 months
- History of clinically significant cardiac arrhythmias or vasospastic disease such as Prinzmetal's angina
- Participation in another clinical trial or receipt of investigational drug within 30 days prior to dosing
- Anemia or blood donation within 30 days prior to dosing
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Johns Hopkins Behavioral Pharmacology Research Unit
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
A
Austin Zamarripa, PhD
CONTACT
L
Lauren S Pollak, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
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