Actively Recruiting
Benefits of Epithelial Repair in COPD by Induced Pluripotent Stem Cells (iPS)
Led by University Hospital, Montpellier · Updated on 2026-05-12
50
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this interventional, cross-sectional and pathophysiological experimental study is to evaluate the potential of a patient's induced pluripotent stem (iPS) cells, used prior to the re-differentiation stage, to enable ex vivo repair of the injured epithelium in patients with chronic obstructive pulmonary disease (COPD), smokers without COPD and non-smoking controls. The main questions it aims to answer are: * to evaluate the repair capacity of bronchial epithelium in COPD subjects, using a model of bronchial epithelium reconstituted in air/liquid interface culture and the iPS model. * epithelia repair capacities in normal or aberrant situations, as well as the time required for this repair, and to determine the involvement of grafted iPS cells in epithelia repair in cultured control subjects, smokers without COPD and COPD patients. Researchers will compare 3 groups of participants (COPD patients, smokers without COPD and non-smokers without COPD) for epithelial repair efficacy between non-grafted ALI cultures and ALI cultures grafted with iPS cells, in order to assess their contribution to epithelial repair. Participants will undergo a bronchial fibroscopy (for clinical indications) with two additional biopsies specific to the study. This research could lead to breakthroughs in cell-based therapies for COPD, with long-term implications for epigenetic treatments and in vivo applications.
CONDITIONS
Official Title
Benefits of Epithelial Repair in COPD by Induced Pluripotent Stem Cells (iPS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female participants aged 18 years or older.
- Participants referred for bronchoscopy by a pulmonologist for clinical reasons such as follow-up, nodule investigation, hemoptysis, cough, sputum production, recurrent bronchitis, or differential diagnosis.
- For COPD group: Current or former smokers with at least 10 pack-years and a confirmed COPD diagnosis (FEV1/FVC < 0.7) by spirometry within the past year.
- For smokers without COPD group: Current or former smokers with at least 10 pack-years and no obstructive ventilatory disorder confirmed by clinical examination and spirometry (FEV1/FVC > 0.7 and FEV1 > 70% predicted) within the past year.
- For non-smoker control group: Never smokers or former smokers who quit more than 10 years ago with less than 10 pack-years and no obstructive ventilatory disorder confirmed by clinical examination and spirometry within the past year.
You will not qualify if you...
- Participants with extensive cancer disease.
- Participants with other progressive lung diseases such as asthma, tuberculosis, interstitial lung disease, or recent/active pulmonary infection.
- Participants who currently use illicit drugs or alcohol.
- Individuals deprived of liberty by legal or administrative decisions or under involuntary hospitalization.
- Individuals enrolled in another research study with an ongoing exclusion period.
- Participants with recent psychiatric disorders preventing informed consent or requiring immediate intervention.
- Adults under legal protection such as guardianship or judicial protection.
- Participants unable to provide informed consent.
- Participants not fluent in French without a trusted person to help with understanding.
- Participants not covered by social security.
- Pregnant or breastfeeding women.
- Participants refusing to give consent after being informed.
- Participants unable or incapable of expressing consent.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital of Montpellier, Arnaud de Villeneuve Hospital
Montpellier, Hérault, France, 34295
Actively Recruiting
Research Team
I
Isabelle VACHIER, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here