Evaluating a 6-Month Individualized Hybrid Physical Activity Program to Improve Quality of Life in Patients Treated for Multiple Myeloma

What this Trial Is About

Researchers are evaluating the effects of a long-term, individualized, hybrid adapted physical activity program on the quality of life of patients treated for multiple myeloma. The study aims to determine if this 6-month program can improve quality of life and impact factors such as effort tolerance, pain, muscle mass, osteolytic lesions, treatment tolerance, and treatment response. Participants will be randomly assigned to either a control group receiving physical activity advice or an intervention group following the adapted physical activity program. The intervention group will engage in a real life hybrid adapted physical activity program combining in-person sessions at the hospital every two weeks for the first three months, then once a month for the following three months, with home-based sessions three times per week over six months. The control group will receive advice about the benefits of physical activity only once at the start of treatment. Both groups will undergo evaluations including a 6-minute walk test, chair stand test, gait-speed test, quadriceps strength assessment, quality of life questionnaires, patient-reported outcomes, treatment tolerance, and response evaluation at inclusion, 3 months, and 6 months. Participants will be involved in scheduled assessments at baseline, 3 months, and 6 months to measure physical function, quality of life, treatment tolerance, and response to treatment. Researchers will monitor the safety and feasibility of the intervention, study changes in physical activity levels, bone pain, muscle mass, osteolytic lesions, and disease-specific patient-reported outcomes. The primary outcome is the comparison of quality of life summary scores at 6 months between groups, with additional measurements taken throughout the study to understand the effects of the physical activity program.

Benefits of a 6-month, Individualized, Hybrid, "Real-life" Adapted Physical Activity Program on the Quality of Life of Patients Treated for Multiple Myeloma