Actively Recruiting
Bespoke ctDNA Assay for Recurrence and Treatment Response Monitoring in Advanced Epithelial Ovarian Cancer
Led by Fudan University · Updated on 2023-12-28
139
Participants Needed
1
Research Sites
278 weeks
Total Duration
On this page
Sponsors
F
Fudan University
Lead Sponsor
B
BGI Tianjin
Collaborating Sponsor
AI-Summary
What this Trial Is About
This prospective observational study is to assess the dynamics of circulating tumor DNA (ctDNA) in patients with advanced epithelial ovarian cancer (EOC) undergoing surgery, adjuvant chemotherapy, followed by poly adenosine diphosphate-ribose polymerase (PARP) inhibitors until disease progression or the end of the study. All patients will be closely monitored throughout the course of disease by a tumor-informed bespoke ctDNA assay as well as traditional methods of surveillance, such as CA125 and imaging. This study may provide preliminary evidence for ctDNA-guided treatment decisions in future clinical practice.
CONDITIONS
Official Title
Bespoke ctDNA Assay for Recurrence and Treatment Response Monitoring in Advanced Epithelial Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female, over 18 years of age
- Advanced epithelial ovarian cancer patients eligible for radical surgery
- Advanced epithelial ovarian cancer patients relapsed from platinum-based therapies eligible for secondary cytoreductive surgery
- Agree to sign informed consent and allow use of samples and data for research
- Agree to provide tissue and blood samples for whole exon sequencing and ctDNA monitoring
You will not qualify if you...
- Diagnosis, testing, or treatment for cancer other than ovarian cancer within 2 years, except definitively treated basal or squamous cell skin cancer
- Pregnancy
- History of blood transfusion within 3 months before enrollment
- Newly diagnosed patients who only had laparoscopic surgery
- Patients who received chemotherapy or other anti-tumor therapy before surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hao Wen
Shanghai, Shanghai Municipality, China, 200023
Actively Recruiting
Research Team
H
Hao Wen, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here