Actively Recruiting
Best Antithrombotic Therapy in Patients With Acute Venous ThromboEmbolism While Taking Antiplatelets
Led by Centre Hospitalier Universitaire de Saint Etienne · Updated on 2026-05-08
1400
Participants Needed
28
Research Sites
276 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire de Saint Etienne
Lead Sponsor
M
Ministry of Health, France
Collaborating Sponsor
AI-Summary
What this Trial Is About
Venous thromboembolism (VTE) and atherosclerotic cardiovascular disease share common risk factors and frequently coexist in the same patients. Their management requires use of antithrombotic agents: anticoagulant therapy (AC) for secondary prevention of VTE recurrence, antiplatelet (AP) for secondary prevention of major adverse ischemic cardiovascular and cerebrovascular event (MACCE) in patients with atherosclerotic cardiovascular disease (coronary artery disease, atherosclerotic cerebrovascular disease, lower extremity peripheral arterial disease). Side effects of antithrombotic drugs are the 1st cause of emergency admission and hospitalization for an adverse drug reaction (mainly bleeding), and the combination of AC with AP strongly increases this risk.
CONDITIONS
Official Title
Best Antithrombotic Therapy in Patients With Acute Venous ThromboEmbolism While Taking Antiplatelets
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Acute symptomatic proximal deep-vein thrombosis or pulmonary embolism confirmed by objective testing
- Indication for full-dose anticoagulant therapy for at least 3 months
- Currently prescribed antiplatelet therapy for secondary prevention of atherosclerotic cardiovascular disease
- Life expectancy longer than 3 months
- Affiliated with social security
You will not qualify if you...
- Unable to provide informed consent
- Active bleeding or high bleeding risk that prevents anticoagulant treatment
- Systolic blood pressure over 180 mm Hg or diastolic blood pressure over 110 mm Hg
- Anticoagulation treatment started more than 5 days before randomization
- Active pregnancy, expected pregnancy, or lack of effective contraception
- Isolated distal deep vein thrombosis
- Antiplatelet therapy prescribed only for primary prevention of cardiovascular disease
- Need to maintain dual-antiplatelet therapy
- Triple positive antiphospholipid syndrome with arterial thrombosis
- Major cardiovascular or cerebrovascular event within 12 months for acute coronary syndrome or within 6 months for cerebrovascular or peripheral arterial diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 28 locations
1
CHU Amiens
Amiens, France
Actively Recruiting
2
CHU Angers
Angers, France
Actively Recruiting
3
CHU Besançon - Hôpital Jean Minjoz
Besançon, France
Actively Recruiting
4
CHRU Brest - Hôpital la Cavale Blanche
Brest, France
Actively Recruiting
5
Clinique du Parc - Castelnau-le -lez
Castelnau-le-Lez, France
Actively Recruiting
6
CHU Clermont-Ferrand - Hôpital Gabriel Montpied
Clermont-Ferrand, France
Actively Recruiting
7
CHU Dijon
Dijon, France
Actively Recruiting
8
CH le Corbusier - Firminy
Firminy, France
Actively Recruiting
9
CHU Grenoble - Hôpital la Tronche
Grenoble, France
Actively Recruiting
10
CH Le Puy - Hôpital Emile Roux
Le Puy-en-Velay, France
Actively Recruiting
11
CHU Limoges
Limoges, France
Actively Recruiting
12
HCL - Hôpital Edouard Herriot
Lyon, France
Actively Recruiting
13
HCL - Lyon Sud
Lyon, France
Actively Recruiting
14
APHM - Hôpital la Timone
Marseille, France
Actively Recruiting
15
CH du Forez - Montbrison
Montbrison, France
Actively Recruiting
16
CHU Montpellier
Montpellier, France
Actively Recruiting
17
CHU Nancy - Hôpitaux de Brabois
Nancy, France
Actively Recruiting
18
CHU Nantes - Hôpital Hôtel-Dieu
Nantes, France
Actively Recruiting
19
CHU de Nice - Hôpital Pasteur
Nice, France
Actively Recruiting
20
APHP - Hôpital Bicêtre
Paris, France
Actively Recruiting
21
APHP - Hôpital Européen Georges Pompidou HEGP
Paris, France
Actively Recruiting
22
APHP - Hôpital Louis Mourier
Paris, France
Actively Recruiting
23
CHU Rouen
Rouen, France
Actively Recruiting
24
CHU Saint-Etienne
Saint-Etienne, France
Actively Recruiting
25
CHU Strasbourg - Nouvel Hôpital Civil
Strasbourg, France
Actively Recruiting
26
CH Toulon - Hôpital Sainte Musse
Toulon, France
Actively Recruiting
27
CHU Toulouse - Hôpital de Rangueil
Toulouse, France
Actively Recruiting
28
CHU Tours
Tours, France
Actively Recruiting
Research Team
L
Laurent BERTOLETTI, MD PhD
CONTACT
C
Carine LABRUYERE
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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