Comparing Ketamine, Propofol, and Their Combination for Rapid Sequence Induction During Surgery A 3-Group Randomized Study

What this Trial Is About

Researchers are evaluating the best hypnotic drug to balance good intubation quality and stable blood pressure during rapid sequence induction RSI in the operating room. This Phase 3 randomized study compares the effects of propofol, ketamine, and a combination of both drugs for patients needing RSI under general anesthesia. The main goal is to see which option allows successful intubation on the first attempt without causing major drops in blood pressure. Participants will receive one of three treatments after pre-oxygenation a direct intravenous injection of propofol at 2 mgkg, ketamine at 2 mgkg, or a combination of ketamine 1 mgkg followed by propofol 1 mgkg. The combination treatment does not require dilution. These treatments are given consecutively in the operating theater and monitored closely during the procedure. During the study, participants will be assessed for successful intubation and blood pressure stability within 10 minutes after hypnotic injection. Researchers will also monitor heart rate, oxygen levels, fluid and medication use, and any complications such as pulmonary aspiration. Tolerance to the drugs will be followed during the recovery room stay and up to seven days after surgery. The study runs from April 2025 to April 2027 and includes detailed safety and effectiveness measurements.

Best Hypnotic Drug Choice for Rapid Sequence Induction in the Operating Room