Actively Recruiting
BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)
Led by Centrum Clinic IVF Center · Updated on 2026-03-19
200
Participants Needed
1
Research Sites
41 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational clinical study aims to determine the optimal timing of ovulation triggering in women aged 35 and above with poor ovarian reserve. For this purpose, cases undergoing ovarian stimulation for assisted reproductive treatment and planned final oocyte triggering will be evaluated in two separate groups: 1. \*\*Experimental Group\*\*: Final oocyte triggering will be performed when the follicle or follicles measure between 13-16 mm. 2. \*\*Control Group\*\*: Final oocyte triggering will be performed when the follicle or follicles measure greater than 17 mm. All triggers will be administered uniformly with 6500 units of recombinant hCG and 0,2 mg triptorelin injections. The primary outcome of the study will be the number of mature oocytes. Secondary outcomes will include fertilization rates, embryo counts, and implantation rates. Primary and secondary outcomes will be compared between the two groups.
CONDITIONS
Official Title
BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women age equal to or greater than 35 years
- Women with low serum AMH (<1.2 ng/ml)
- Women with low antral follicle count (AFC) (<5)
- Women undergoing assisted reproduction with short antagonist or long agonist protocols
- Women who have used a maximum daily gonadotropin dose of 300 IU during stimulation
You will not qualify if you...
- Age under 35 years
- Ovarian reserve parameters not meeting POSEIDON group 4 definition
- Natural or modified natural cycles without controlled ovarian stimulation
- In vitro maturation (IVM) cycles
- Luteal-phase stimulation or DuoStim protocols
- Preimplantation genetic testing (PGT) cycles unless prespecified for analysis
- Major untreated uterine cavity pathology or untreated hydrosalpinx
- Missing or incomplete follicular measurement data on trigger day
- Non-standardized or undocumented trigger-to-oocyte retrieval intervals
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centrum Clinic IVF Center
Ankara, Ankara, Turkey (Türkiye), 06800
Actively Recruiting
Research Team
E
Emre G Pabuccu, Professor
CONTACT
R
Recai Pabuccu, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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