Optimal Timing for Ovulation Trigger in Women Aged 35 to 44 with Poor Ovarian Reserve Undergoing IVF

What this Trial Is About

Researchers are evaluating the best timing for ovulation triggering in women aged 35 and older who have a poor ovarian reserve and are undergoing assisted reproductive treatment. This observational study focuses on determining whether triggering ovulation when follicles measure between 13-16 mm compared to when follicles are larger than 17 mm results in a higher number of mature eggs. The study addresses the challenge of obtaining enough mature eggs in older women with low ovarian reserve, an area where current standard practices may not be optimal. Participants will be divided into two groups based on follicle size at the time of ovulation triggering the experimental group triggers at 13-16 mm follicle size, while the control group triggers at larger than 17 mm. All participants receive the same ovulation trigger treatment consisting of 6500 units of recombinant hCG and 0.2 mg triptorelin injections. Ovarian stimulation is monitored through serial ultrasounds and hormone measurements during the treatment period. During the study, women will undergo regular ultrasound exams and hormone tests to track follicle development and ovulation timing. Researchers will compare the number of mature eggs retrieved, fertilization rates, embryo counts, and implantation rates between the two groups. The primary measurement is the change in the number of mature eggs from enrollment to the end of treatment over 6 to 8 months. This study is sponsored by Centrum Clinic IVF Center and participation duration may vary depending on individual treatment schedules.

BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)