Actively Recruiting
Beta-Blocker Influences on Inflammatory and Neural Responses to Stress
Led by University of North Carolina, Chapel Hill · Updated on 2025-10-29
120
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
U
University of North Carolina, Chapel Hill
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.
CONDITIONS
Official Title
Beta-Blocker Influences on Inflammatory and Neural Responses to Stress
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18-30 years
- Right-handed
- Fluent in English reading, writing, and speaking at least at a 10th grade level
- Body mass index (BMI) less than or equal to 35 kg/m^2
You will not qualify if you...
- Presence of non-removable metal devices, implants, or objects in the body
- Severe claustrophobia
- Currently pregnant
- Left-handed
- Body mass index (BMI) greater than 35 kg/m^2
- History of fainting spells or any heart condition
- History or presence of low resting heart rate (< 60 BPM) or low blood pressure (systolic < 80mmHg)
- Self-reported physical illnesses including diabetes, cardiovascular diseases, high blood pressure, inflammatory bowel diseases, rheumatoid arthritis, asthma, autoimmune disease, Crohn's disease, ulcerative colitis, lupus
- Any self-reported diagnosed mental illness
- Current use of prescription medications (except hormonal contraceptives)
- Current or recent regular nicotine/tobacco use
- Current regular recreational drug use 4 or more times per week
- Received any vaccine within the past two weeks
- Severe sleep disturbance the night before Session II
- Vigorous physical activity on the day of Session II
- Acute illness or allergy symptoms on the day of Session II
- Use of over-the-counter medications on the day of Session II
- Use of recreational drugs within 48 hours of Session II
- Use of alcohol on the day of Session II
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Social Neuroscience and Health Laboratory
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
Research Team
J
Jonathan Bunting, BS
CONTACT
K
Keely A Muscatell, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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