Actively Recruiting

Phase 4
Age: 18Years +
All Genders
NCT06766461

Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis

Led by Erasmus Medical Center · Updated on 2025-01-09

980

Participants Needed

1

Research Sites

151 weeks

Total Duration

On this page

Sponsors

E

Erasmus Medical Center

Lead Sponsor

M

Maasstad Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

The aim of this study is to investigate if an initial short double dose of beta-lactam antibiotics will reduce mortality in critically ill patients with sepsis.

CONDITIONS

Official Title

Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • 18 years of age or older
  • Receiving intravenous antibiotic therapy of the target drugs, including continuous infusion of beta-lactam antibiotics
  • Have a primary infection
  • Admitted to the intensive care unit (ICU)
  • Meet the Sepsis-3 criteria for septic shock: sepsis with shock needing vasopressors to keep mean arterial pressure 65 mmHg or higher and serum lactate greater than 2.0 mmol/L after adequate fluid resuscitation
Not Eligible

You will not qualify if you...

  • Patient or legal representative not available to give informed consent within 72 hours after admittance
  • Pregnancy
  • Admitted for burn wounds
  • Receiving target antibiotics only as prophylaxis in Selective Digestive tract Decontamination (SDD)
  • Enrolled in another interventional trial
  • Received study antibiotic for more than 24 hours before inclusion
  • Receiving extracorporeal membrane oxygenation (ECMO)
  • Already treated with a double dose of antibiotics based on suspected infection

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Maasstad Ziekenhuis

Rotterdam, Netherlands

Actively Recruiting

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Research Team

B

Birgit C.P. Koch, PharmD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis | DecenTrialz