Actively Recruiting
Beverage Hydration Index of Different Solutions
Led by University of Memphis · Updated on 2026-04-07
30
Participants Needed
1
Research Sites
18 weeks
Total Duration
On this page
Sponsors
U
University of Memphis
Lead Sponsor
P
PharmaLinea Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this study, the impact of two electrolyte hydration stick products (Hydramin containing an electrolyte/amino acid formulation and an identical electrolyte product with the amino-acids replaced with carbohydrate, dextrose) dissolved in 1 liter of water will be assessed and compared to a control (1 liter Smart Water). It is hypothesized that the addition of amino acids and glycine should improve the Beverage Hydration Index above water alone and perform comparably to the carbohydrate rich solution. This study will focus on general population (not athletes) and follow very similar approaches used in previous studies within the Center for Nutraceutical and Dietary Supplements Research, with the addition of blood glucose testing and body water measurements. Hydration will be assessed via fluid balance (the difference between the amount of water consumed and passed as urine) and calculations of beverage hydration index (the relative amount of urine passed after consumption of a drink compared to water)as well as time in positive fluid balance, and specific gravity, and sodium and potassium in urine. Blood glucose before and following consumption using finger pricks and a glucometer will also be assessed.
CONDITIONS
Official Title
Beverage Hydration Index of Different Solutions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be age 18 years or older
- Male or female
- Have a body mass index (BMI) between 18.5-35 kg/m2
- Engage in moderate physical activity, defined as 4 hours/week of aerobic exercise
- Be without clinically relevant cardiac, renal, hepatic, endocrine (including diabetes), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorders
- Not have conditions likely to alter fluid balance or be negatively affected by changing electrolyte levels/hydration status
- Not consume medications that alter fluid retention or electrolyte levels such as SSRIs, SGLT2 inhibitors, laxatives, diuretics, Apremilast, chemotherapy, or lithium
- Avoid nutritional supplements, performance enhancing drugs, and non-steroidal anti-inflammatory drugs within 7 days of study visits (excluding screening)
- Follow lifestyle and dietary restrictions before study visits including avoiding strenuous activity for 24 hours prior, refraining from caffeine for 12 hours and alcohol for 24 hours, consuming a standardized diet and similar activity levels for 24 hours prior, consuming 2.5 liters for men or 2.0 liters for women the day prior, and fasting at least 10 hours prior
- Not be sensitive or allergic to any study intervention components
- Not use tobacco
- Not follow specialized dietary patterns like low carbohydrate/ketogenic, carnivore diet, or intermittent fasting
- Arrive to lab visits euhydrated (USG 1.005-1.020)
- Willing and able to fast (water only) for 15 hours (10 hours prior to lab visits excluding screening)
- Not be enrolled in another clinical study within 30 days of first visit
- Be free of active infection or illness
- Not be pregnant or breastfeeding
- Not have had surgery in the previous 4 months
You will not qualify if you...
- History or presence of clinically relevant cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorder
- Conditions likely to alter fluid balance or negatively affect hydration status
- Use of medications altering fluid retention or electrolyte levels such as SSRIs, SGLT2 inhibitors, laxatives, diuretics, Apremilast, chemotherapy, or lithium
- Use of nutritional supplements, performance enhancing drugs, or non-steroidal anti-inflammatory drugs within 7 days of study visits (excluding screening)
- Sensitivity or allergy to any components of study beverages
- Tobacco use
- Following specialized dietary patterns that may alter study findings
- Not arriving euhydrated to lab visits
- Inability or unwillingness to fast as required
- Enrollment in another clinical study within 30 days prior
- Active infection or illness
- Pregnancy or breastfeeding
- Surgery within the previous 4 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Center for Nutraceutical and Dietary Supplement Research
Memphis, Tennessee, United States, 38152
Actively Recruiting
Research Team
J
Jacquelyn Pence, PhD
CONTACT
R
Richard Bloomer, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
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