Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
ID07507344

Comparison of the Beverage Hydration Index of Different Solutions

Led by University of Memphis · Updated on 2026-04-07

30

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

U

University of Memphis

Lead Sponsor

P

PharmaLinea Ltd.

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to compare the hydration effects of two electrolyte hydration stick products and plain water in healthy adults. The study focuses on the general population rather than athletes and evaluates how adding amino acids or carbohydrates to electrolyte solutions impacts hydration. Researchers will assess hydration by measuring fluid balance, beverage hydration index, urine composition, and blood glucose levels. Participants will attend multiple visits during which they consume one liter of a randomly assigned solution in four equal parts over 30 minutes, followed by four hours of monitoring. The solutions tested include a Hydramin electrolyte and amino acid drink, an electrolyte and carbohydrate drink, and plain water. Each participant experiences all three beverages in varied orders across visits. Throughout the study, participants undergo various assessments including urine tests for sodium, potassium, and specific gravity, blood glucose monitoring using finger pricks, body water measurement, and mood and digestive questionnaires. Vital signs such as blood pressure and heart rate are also recorded at multiple time points. The total observation for each visit spans about 4.5 hours, allowing detailed monitoring of hydration and metabolic responses.

CONDITIONS

Brief Title

Beverage Hydration Index of Different Solutions

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Be age 18 years or older
  • Male or female
  • Body mass index (BMI) between 18.5 and 35 kg/m2
  • Engage in moderate aerobic exercise up to 5 hours per week
  • Arrive hydrated to study visits having consumed standardized meal replacements the day before
  • Ability and willingness to fast (water only) for at least 10 hours prior to lab visits
  • No enrollment in another clinical study within 30 days prior to first visit
  • Be without active infection or illness at study visits
Not Eligible

You will not qualify if you...

  • History or presence of clinically relevant cardiac, renal, hepatic, endocrine (including diabetes), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorders
  • Conditions likely to alter fluid balance or negatively affected by electrolyte changes
  • Use of medications altering fluid retention or electrolyte levels such as SSRIs, SGLT2 inhibitors, laxatives, diuretics, Apremilast, chemotherapy, or lithium
  • Use of nutritional supplements, performance-enhancing drugs, or NSAIDs within 7 days of visits
  • Sensitivity or allergy to any study intervention components
  • Tobacco use
  • Following specialized dietary patterns like ketogenic or intermittent fasting
  • Not arriving euhydrated (urine specific gravity outside 1.005-1.020)
  • Pregnant or breastfeeding
  • Surgery within 4 months prior to study visits
  • Inability to fast or follow study lifestyle restrictions before visits

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Three visits over the course of the trial

Participants will attend three visits where they consume 1 liter of a hydration solution (Hydramin, Electrolyte and Carbohydrate, or Water) over 30 minutes, followed by monitoring for four hours after consumption. Participants arrive hydrated, having consumed standardized meal replacements the day before each visit.

3 visits (in-person), each including beverage consumption and 4 hours of monitoring

Trial Site Locations

Total: 1 location

1

Center for Nutraceutical and Dietary Supplement Research

Memphis, Tennessee, United States, 38152

Actively Recruiting

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Research Team

J

Jacquelyn Pence, PhD

R

Richard Bloomer, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

6

Frequently Asked Questions

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