Investigating the Origins of Pelvic Recurrence in Colorectal Cancer Using a New Radiological Staging Classification System

What this Trial Is About

Researchers are studying patients with recurrent colorectal cancer in the pelvis to improve surgical and treatment planning. The study focuses on evaluating a new imaging assessment proforma that details anatomic pelvic compartments and causes of disease recurrence. This research aims to better understand risk factors for recurrence by reviewing original tumor staging scans and surgical specimens. The study is prospective and retrospective, led by Imperial College London, and involves advanced colorectal cancers undergoing pelvic exenterative surgery. Participants will undergo a new radiological staging classification system using high-resolution MRI to assess tumor distribution in the pelvis. This new system is being evaluated to help surgeons decide which patients are suitable for radical surgery and to improve surgical planning. The imaging assessment proformas will be implemented to classify pelvic compartments and recurrence types, guiding treatment decisions. The study includes follow-up periods extending to three years to monitor outcomes. During the study, researchers will collect and analyze imaging scans, histopathology reports, and treatment data. Participants will be followed for up to three years to measure outcomes such as surgical success rates, recurrence types, quality of life after treatment, and healthcare costs. The study will compare MRI findings with clinical outcomes and histopathology to validate the staging system. Various assessments will be done at intervals from one to five years to evaluate prognosis, treatment effects, and inter-observer agreement on MRI classifications.

Beyond TME Origins