Actively Recruiting
Bi-atrial Versus Left Atrial Ablation for Patients With Rheumatic Mitral Valve Disease and Non-paroxysmal Atrial Fibrillation
Led by China National Center for Cardiovascular Diseases · Updated on 2024-06-13
320
Participants Needed
2
Research Sites
164 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is aimed to compare the efficacy of bi-atrial ablation with left atrial ablation for atrial fibrillation during mitral valve surgery in patients with rheumatic mitral valve disease.
CONDITIONS
Official Title
Bi-atrial Versus Left Atrial Ablation for Patients With Rheumatic Mitral Valve Disease and Non-paroxysmal Atrial Fibrillation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of persistent atrial fibrillation or long-standing persistent atrial fibrillation confirmed by medical history and Holter monitoring
- Rheumatic mitral valve disease requiring mitral valve surgery confirmed by history, valve morphology, echocardiography, and pathological diagnosis
- Agreement to undergo surgical ablation of atrial fibrillation
You will not qualify if you...
- Paroxysmal atrial fibrillation
- Degenerative or ischemic mitral valve disease
- Evidence of active infection
- Previous catheter or surgical ablation for atrial fibrillation
- Surgical treatment for hypertrophic obstructive cardiomyopathy
- Absolute contraindications to anticoagulation therapy
- Left atrial thrombosis (except left atrial appendage thrombosis alone)
- Severe chronic obstructive pulmonary disease (FEV1 <30% predicted)
- Uncontrolled hypo- or hyperthyroidism
- Mental impairment or other conditions preventing understanding of the study
- Left atrial diameter greater than 70 mm
- Right ventricular dysfunction (TAPSE <16), moderate to severe tricuspid regurgitation, or pulmonary artery pressure over 60 mmHg
- Need for coronary artery bypass grafting due to coronary heart disease
- Previous cardiac surgery
- Refusal to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Fuwai Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
2
Nanjing First Hospital, Nanjing Medical University
Nanjing, Jiangsu, China
Actively Recruiting
Research Team
Z
Zhe Zheng, MD,PhD
CONTACT
C
Chunyu Yu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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