Actively Recruiting
A Bidirectional Cohort Study on Prophylactic Resection Surgery in Populations at Moderate-to-High Risk for Hereditary Ovarian Cancer
Led by Peking University Third Hospital · Updated on 2026-04-15
480
Participants Needed
1
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this multi-center observational study is to learn about the effectiveness and safety of different prophylactic (preventive) surgical options in women at moderate-to-high genetic risk for hereditary ovarian cancer (HOC). The main questions it aims to answer are: Does individualized prophylactic surgery (such as removing fallopian tubes now and delaying ovary removal) effectively reduce the risk of developing ovarian cancer compared to standard care or close monitoring? How do these different surgical interventions affect a woman's ovarian function and quality of life? What Participants Will Do: Participants who are healthy carriers of specific genetic mutations (such as BRCA1/2, RAD51C/D, etc.) will be followed in a bidirectional cohort. Depending on the medical care and surgical path they choose with their doctors (Standard RRSO, Delayed Oophorectomy, or Close Monitoring), researchers will collect their clinical data, surgical pathology results, and follow-up information regarding cancer incidence and quality of life for 3 years.
CONDITIONS
Official Title
A Bidirectional Cohort Study on Prophylactic Resection Surgery in Populations at Moderate-to-High Risk for Hereditary Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female gender, 18 years or older at enrollment
- Carriers of pathogenic or likely pathogenic mutations in high-risk ovarian cancer genes (BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2)
- Willing to provide informed consent and allow access to medical and genetic records
- Ability to complete quality of life and psychological assessments (e.g., GCS, SF-36, FSFI)
You will not qualify if you...
- History of ovarian, fallopian tube, or primary peritoneal cancer before baseline intervention
- Diagnosis of any other advanced-stage cancer
- Significant psychological, social, or geographic barriers preventing regular 3-year follow-up
- Prior extensive pelvic surgery that prevents laparoscopic prophylactic salpingectomy or oophorectomy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
Research Team
A
Associate Chief Physician/Associate Consultant, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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