Actively Recruiting
A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC
Led by Zhujiang Hospital · Updated on 2025-08-21
35
Participants Needed
1
Research Sites
233 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A prospective collection of 35 cases was conducted at Zhujiang Hospital of Southern Medical University. Patients diagnosed with locally advanced oral squamous cell carcinoma (LA-OSCC) or locally advanced oropharyngeal squamous cell carcinoma (LA-OPSCC) from April 2023 onward, who received two cycles of neoadjuvant immunochemotherapy (tislelizumab + paclitaxel + cisplatin/carboplatin) at our institution, were included. The study analyzed treatment safety, efficacy, tumor regression patterns, 2-year progression-free survival (PFS), and 5-year overall survival (OS) rates.
CONDITIONS
Official Title
A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with locally advanced oral or oropharyngeal squamous cell carcinoma (T3-4 stage)
- Aged between 18 and 80 years
- No history of other malignant tumors or prior cancer treatment
- White blood cell count of at least 3.5 x 10^9/L
- Platelet count of at least 75 x 10^9/L
- Hemoglobin concentration of at least 90 g/L
- Total bilirubin level within normal limits
- Aspartate aminotransferase and alanine aminotransferase levels no more than 2.5 times the upper normal limit
- Urinary white blood cells less than 10 per high-power field
- Urinary red blood cells less than 10 per high-power field
- Urinary cast count less than 5 per high-power field
- Creatinine level within normal limits
- Heart, brain, lung, and other vital organs functioning well enough to tolerate neoadjuvant immunochemotherapy and surgery
- Performance status score of 2 or less
You will not qualify if you...
- Presence of distant metastasis
- Pregnant or lactating women
- Unable to cooperate with regular follow-up due to psychological, social, family, or geographical reasons
- Currently receiving investigational treatment in another clinical study
- Severe uncontrolled infection or medical illness
- Major organ dysfunction such as decompensated heart, lung, kidney, or liver failure
- Conditions affecting surgery or anesthesia due to severe organ dysfunction
- Long-term use of immunosuppressive drugs after organ transplantation
- History of other malignant tumors before enrollment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Stomatology, Zhujiang Hospital, Southern Medical University,Guangzhou, Guangdong
Guangzhou, Guangdong, China
Actively Recruiting
Research Team
X
Xiaozhi LV
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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