Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID07360392

Comparison of Postoperative Analgesic Effects of BiFeS Block Versus iPACK Block Combined with Adductor Canal Block in Knee Arthroplasty

Led by Amasya University · Updated on 2026-04-22

88

Participants Needed

1

Research Sites

13 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating a new technique called the Biceps Femoris Short Head (BiFeS) block, combined with the adductor canal block (ACB), for pain relief after total knee arthroplasty, a surgery to treat advanced osteoarthritis. This study compares the BiFeS block plus ACB to the ACB plus iPACK block, aiming to find which combination provides better postoperative pain control while preserving motor function. The trial is designed as a prospective, randomized, double-blind study involving two groups of patients undergoing knee replacement surgery. Participants will be randomly assigned to receive either the ACB combined with the iPACK block or the ACB combined with the BiFeS block. Both blocks use ultrasound guidance to inject bupivacaine anesthetic near specific nerves around the knee to reduce pain without affecting muscle strength. The BiFeS block targets sensory nerves around the posterolateral knee capsule. The study carefully monitors and compares the effectiveness of these two motor-sparing regional anesthesia techniques during and after surgery. During the trial, participants will have pain scores measured at multiple time points up to three months after surgery, including rest and movement pain levels. Researchers will also track opioid use, time to rescue pain medication, early mobilization, quality of recovery, and any complications like nausea or vomiting. Assessments include questionnaires and physical therapy criteria for hospital discharge. The total follow-up period extends to three months, allowing detailed evaluation of pain control and functional recovery after knee replacement surgery.

CONDITIONS

Brief Title

BiFeS vs. iPACK in Postoperative Knee Arthroplasty Analgesia

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Scheduled for unilateral total knee arthroplasty
  • Classified as ASA physical status I-III
  • Age between 18 and 80 years
  • All genders eligible
Not Eligible

You will not qualify if you...

  • Scheduled for revision arthroplasty or bilateral surgery
  • Allergy to local anesthetics or contraindications to regional blocks
  • Neurological disorders or peripheral neuropathy affecting lower limb muscle strength
  • Coagulopathy or on anticoagulant therapy
  • History of severe liver, kidney, or heart failure
  • Chronic opioid use or history of substance abuse
  • Intraoperative complications such as excessive bleeding
  • Inadequate sensory blockade after the nerve block procedure

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Up to 3 days post-surgery

Participants undergo total knee arthroplasty and receive either the BiFeS block combined with adductor canal block or the iPACK block combined with adductor canal block for postoperative pain control.

Multiple assessments during the first 72 hours postoperatively

Follow-up

Duration - 3 months

Participants are monitored for pain scores, analgesic use, complications, and recovery up to 3 months after surgery.

Assessments at 1 and 3 months postoperatively

Trial Site Locations

Total: 1 location

1

Amasya University Sabuncuoğlu Şerefeddin Training and Research Hospital

Amasya, Turkey (Türkiye), 05200

Actively Recruiting

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Research Team

B

Bülent M Çam, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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