Actively Recruiting
Comparison of Postoperative Analgesic Effects of BiFeS Block Versus iPACK Block Combined with Adductor Canal Block in Knee Arthroplasty
Led by Amasya University · Updated on 2026-04-22
88
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a new technique called the Biceps Femoris Short Head (BiFeS) block, combined with the adductor canal block (ACB), for pain relief after total knee arthroplasty, a surgery to treat advanced osteoarthritis. This study compares the BiFeS block plus ACB to the ACB plus iPACK block, aiming to find which combination provides better postoperative pain control while preserving motor function. The trial is designed as a prospective, randomized, double-blind study involving two groups of patients undergoing knee replacement surgery. Participants will be randomly assigned to receive either the ACB combined with the iPACK block or the ACB combined with the BiFeS block. Both blocks use ultrasound guidance to inject bupivacaine anesthetic near specific nerves around the knee to reduce pain without affecting muscle strength. The BiFeS block targets sensory nerves around the posterolateral knee capsule. The study carefully monitors and compares the effectiveness of these two motor-sparing regional anesthesia techniques during and after surgery. During the trial, participants will have pain scores measured at multiple time points up to three months after surgery, including rest and movement pain levels. Researchers will also track opioid use, time to rescue pain medication, early mobilization, quality of recovery, and any complications like nausea or vomiting. Assessments include questionnaires and physical therapy criteria for hospital discharge. The total follow-up period extends to three months, allowing detailed evaluation of pain control and functional recovery after knee replacement surgery.
CONDITIONS
Brief Title
BiFeS vs. iPACK in Postoperative Knee Arthroplasty Analgesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled for unilateral total knee arthroplasty
- Classified as ASA physical status I-III
- Age between 18 and 80 years
- All genders eligible
You will not qualify if you...
- Scheduled for revision arthroplasty or bilateral surgery
- Allergy to local anesthetics or contraindications to regional blocks
- Neurological disorders or peripheral neuropathy affecting lower limb muscle strength
- Coagulopathy or on anticoagulant therapy
- History of severe liver, kidney, or heart failure
- Chronic opioid use or history of substance abuse
- Intraoperative complications such as excessive bleeding
- Inadequate sensory blockade after the nerve block procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 days post-surgery
Participants undergo total knee arthroplasty and receive either the BiFeS block combined with adductor canal block or the iPACK block combined with adductor canal block for postoperative pain control.
Multiple assessments during the first 72 hours postoperatively
Duration - 3 months
Participants are monitored for pain scores, analgesic use, complications, and recovery up to 3 months after surgery.
Assessments at 1 and 3 months postoperatively
Trial Site Locations
Total: 1 location
1
Amasya University Sabuncuoğlu Şerefeddin Training and Research Hospital
Amasya, Turkey (Türkiye), 05200
Actively Recruiting
Research Team
B
Bülent M Çam, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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