Study of Bilateral Single-Electrode Ventralis Oralis Combined With Subthalamic Nucleus Deep Brain Stimulation for Treating Meige Syndrome

What this Trial Is About

Meige syndrome is a rare and challenging movement disorder that causes involuntary muscle contractions affecting the eyes, jaw, and neck. It often does not respond well to medications. Researchers are studying the safety and effects of a new approach using deep brain stimulation DBS targeting two brain areas the ventralis oralis VO nucleus and the subthalamic nucleus STN in patients with Meige syndrome to potentially improve symptoms. Participants will receive surgery to implant electrodes in both brain areas. After the device is turned on, one group will first receive stimulation only in the VO area, and the other group will receive stimulation only in the STN area. After three months, both groups will receive combined stimulation in both brain targets. This study is randomized and double-blind to compare the effects of these treatments. Participants will be evaluated for symptom improvement using the Burke-Fahn-Marsden Dystonia Rating Scale over one year after stimulation begins. Other assessments include quality of life, anxiety, depression, and cognitive tests. Researchers will monitor any side effects related to the DBS procedure. The study results aim to guide future treatment options for Meige syndrome.

Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome