Actively Recruiting
Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome
Led by Huashan Hospital · Updated on 2025-04-04
20
Participants Needed
1
Research Sites
95 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Meige syndrome is a rare and debilitating movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical muscle contractions, often refractory to pharmacological therapies. Deep brain stimulation (DBS), initially developed to treat essential tremor and Parkinson's disease, has been explored in recent years as a potential treatment for various dystonias, including Meige's syndrome. This clinical study aims to evaluate the safety and efficacy of bilateral single-electrode ventralis oralis (VO) nucleus stimulation combined with subthalamic nucleus deep brain stimulation (STN-DBS) in patients with Meige syndrome.
CONDITIONS
Official Title
Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must meet the clinical diagnostic criteria for Meige syndrome
- Only includes patients with: Blepharospasm-type Meige syndrome and Blepharospasm with lower jaw muscle dystonia-type
- All patients must have undergone at least one year of systematic and standard treatment prior to surgery
You will not qualify if you...
- History of neurological diseases other than Meige syndrome
- Severe cognitive impairment
- Severe psychiatric disorders
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Huashan Hospital, Fudan University.
Shanghai, Shanghai Municipality, China, 200040
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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